成为GEM：生物含，环境应用，基因工程微生物

IF 15.2 1区医学 Q1 PHARMACOLOGY & PHARMACY

Advanced drug delivery reviews Pub Date : 2025-04-11 DOI:10.1016/j.addr.2025.115578

Tae Seok Moon

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引用次数: 0

摘要

工程生物学或合成生物学的技术进步使基因工程微生物（GEM）得以实际应用，包括用作活体诊断和治疗工具。然而，在充分发挥 GEMs 的潜力之前，与 GEMs 生物封闭相关的技术和非技术问题仍有待解决。在这篇短文中，我将简要讨论 GEM 生物封闭的相关技术以及环境影响、监管问题和公众对 GEM 的看法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Be a GEM: Biocontained, environmentally applied, genetically engineered microbes

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Be a GEM: Biocontained, environmentally applied, genetically engineered microbes

Technological advances in engineering biology or synthetic biology have enabled practical applications of genetically engineered microbes (GEMs), including their use as living diagnostics and vehicles for therapeutics. However, technological and non-technological issues associated with biocontainment of GEMs have yet to be addressed before fully realizing their potential. In this short perspective, I briefly discuss the relevant technologies for GEM biocontainment as well as environmental impacts, regulatory issues, and public perception of GEMs.

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来源期刊

Advanced drug delivery reviews 医学-药学

CiteScore

28.10

自引率

5.00%

发文量

294

审稿时长

15.1 weeks

期刊介绍： The aim of the Journal is to provide a forum for the critical analysis of advanced drug and gene delivery systems and their applications in human and veterinary medicine. The Journal has a broad scope, covering the key issues for effective drug and gene delivery, from administration to site-specific delivery. In general, the Journal publishes review articles in a Theme Issue format. Each Theme Issue provides a comprehensive and critical examination of current and emerging research on the design and development of advanced drug and gene delivery systems and their application to experimental and clinical therapeutics. The goal is to illustrate the pivotal role of a multidisciplinary approach to modern drug delivery, encompassing the application of sound biological and physicochemical principles to the engineering of drug delivery systems to meet the therapeutic need at hand. Importantly the Editorial Team of ADDR asks that the authors effectively window the extensive volume of literature, pick the important contributions and explain their importance, produce a forward looking identification of the challenges facing the field and produce a Conclusions section with expert recommendations to address the issues.