Bolu Sun, Chengyang Gao, Haiying He, Dai Li, Miao Zhou, Xuanxiu Da, Ke Sun, Guolin Chai, Quan Hao, Fangdi Hu, Lingbin Kong
{"title":"基于CS/ACK@CeO2/GCE的新型电化学传感器用于黄芩苷的高选择性和高灵敏度分析","authors":"Bolu Sun, Chengyang Gao, Haiying He, Dai Li, Miao Zhou, Xuanxiu Da, Ke Sun, Guolin Chai, Quan Hao, Fangdi Hu, Lingbin Kong","doi":"10.1007/s10008-024-06143-7","DOIUrl":null,"url":null,"abstract":"<div><p>Baicalin is an index component used for the quality evaluation of <i>Scutellaria baicalensis</i> <i>Georgi</i> with significant anticancer activity. It is very important to develop a highly selective and sensitive method for the detection of baicalin in complex samples, which is used for standardized planting, harvesting, and processing of <i>Scutellaria baicalensis</i>, quality control of <i>Scutellaria baicalensis</i> herbs and products. Based on this, a novel electrochemical sensor based on CS/ACK@CeO<sub>2</sub>-NPs composite material was constructed for the rapid and sensitive detection of baicalin in complex samples. It is noteworthy that cerium oxide nanoparticles (CeO<sub>2</sub>-NPs) were loaded on the KMnO<sub>4</sub>-modified activated carbon (ACK) and used in the construction of electrochemical sensors for the first time. The number of micropores of ACK was significantly increased, and the specific surface area of the material was effectively increased. The combination of ACK with cerium oxide nanoparticles (CeO<sub>2</sub>-NPs) avoided the agglomeration of CeO<sub>2</sub>-NPs, which produced a significant synergistic effect, increased the electron transfer rate, and provided more active adsorption sites for electron transfer. In addition, chitosan (CS) has good film-forming performance, so adding CS to the ACK@CeO<sub>2</sub>-NPs system not only improves the film-forming performance and mechanical properties but also makes the constructed sensor more stable and sensitive. After optimizing the conditions, the test displayed good linearity in the concentration range (2.24 × 10<sup>−4</sup> ~ 4.48 × 10<sup>−7</sup> mol/L) of baicalin with the lowest detection limit of 4.81 × 10<sup>−9</sup> mol/L (<i>S</i>/<i>N</i> = 3) when it is used for the detection of baicalin in complex samples. This method provides a new approach for the rapid and sensitive detection of baicalin in complex samples. The application of electrochemical analysis techniques to the instant monitoring of active or indicator components in the materials of traditional Chinese medicine (TCM) and their preparations is expected to provide a sensitive, rapid, and reliable monitoring and analysis technique for the quality control of TCM and their products throughout their life cycle.</p></div>","PeriodicalId":665,"journal":{"name":"Journal of Solid State Electrochemistry","volume":"29 5","pages":"2037 - 2049"},"PeriodicalIF":2.6000,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A novel electrochemical sensor based on CS/ACK@CeO2/GCE for high selectivity and sensitivity analysis of baicalin in complex samples\",\"authors\":\"Bolu Sun, Chengyang Gao, Haiying He, Dai Li, Miao Zhou, Xuanxiu Da, Ke Sun, Guolin Chai, Quan Hao, Fangdi Hu, Lingbin Kong\",\"doi\":\"10.1007/s10008-024-06143-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Baicalin is an index component used for the quality evaluation of <i>Scutellaria baicalensis</i> <i>Georgi</i> with significant anticancer activity. It is very important to develop a highly selective and sensitive method for the detection of baicalin in complex samples, which is used for standardized planting, harvesting, and processing of <i>Scutellaria baicalensis</i>, quality control of <i>Scutellaria baicalensis</i> herbs and products. Based on this, a novel electrochemical sensor based on CS/ACK@CeO<sub>2</sub>-NPs composite material was constructed for the rapid and sensitive detection of baicalin in complex samples. It is noteworthy that cerium oxide nanoparticles (CeO<sub>2</sub>-NPs) were loaded on the KMnO<sub>4</sub>-modified activated carbon (ACK) and used in the construction of electrochemical sensors for the first time. The number of micropores of ACK was significantly increased, and the specific surface area of the material was effectively increased. The combination of ACK with cerium oxide nanoparticles (CeO<sub>2</sub>-NPs) avoided the agglomeration of CeO<sub>2</sub>-NPs, which produced a significant synergistic effect, increased the electron transfer rate, and provided more active adsorption sites for electron transfer. In addition, chitosan (CS) has good film-forming performance, so adding CS to the ACK@CeO<sub>2</sub>-NPs system not only improves the film-forming performance and mechanical properties but also makes the constructed sensor more stable and sensitive. After optimizing the conditions, the test displayed good linearity in the concentration range (2.24 × 10<sup>−4</sup> ~ 4.48 × 10<sup>−7</sup> mol/L) of baicalin with the lowest detection limit of 4.81 × 10<sup>−9</sup> mol/L (<i>S</i>/<i>N</i> = 3) when it is used for the detection of baicalin in complex samples. This method provides a new approach for the rapid and sensitive detection of baicalin in complex samples. The application of electrochemical analysis techniques to the instant monitoring of active or indicator components in the materials of traditional Chinese medicine (TCM) and their preparations is expected to provide a sensitive, rapid, and reliable monitoring and analysis technique for the quality control of TCM and their products throughout their life cycle.</p></div>\",\"PeriodicalId\":665,\"journal\":{\"name\":\"Journal of Solid State Electrochemistry\",\"volume\":\"29 5\",\"pages\":\"2037 - 2049\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2024-11-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Solid State Electrochemistry\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10008-024-06143-7\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ELECTROCHEMISTRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Solid State Electrochemistry","FirstCategoryId":"5","ListUrlMain":"https://link.springer.com/article/10.1007/s10008-024-06143-7","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ELECTROCHEMISTRY","Score":null,"Total":0}
A novel electrochemical sensor based on CS/ACK@CeO2/GCE for high selectivity and sensitivity analysis of baicalin in complex samples
Baicalin is an index component used for the quality evaluation of Scutellaria baicalensisGeorgi with significant anticancer activity. It is very important to develop a highly selective and sensitive method for the detection of baicalin in complex samples, which is used for standardized planting, harvesting, and processing of Scutellaria baicalensis, quality control of Scutellaria baicalensis herbs and products. Based on this, a novel electrochemical sensor based on CS/ACK@CeO2-NPs composite material was constructed for the rapid and sensitive detection of baicalin in complex samples. It is noteworthy that cerium oxide nanoparticles (CeO2-NPs) were loaded on the KMnO4-modified activated carbon (ACK) and used in the construction of electrochemical sensors for the first time. The number of micropores of ACK was significantly increased, and the specific surface area of the material was effectively increased. The combination of ACK with cerium oxide nanoparticles (CeO2-NPs) avoided the agglomeration of CeO2-NPs, which produced a significant synergistic effect, increased the electron transfer rate, and provided more active adsorption sites for electron transfer. In addition, chitosan (CS) has good film-forming performance, so adding CS to the ACK@CeO2-NPs system not only improves the film-forming performance and mechanical properties but also makes the constructed sensor more stable and sensitive. After optimizing the conditions, the test displayed good linearity in the concentration range (2.24 × 10−4 ~ 4.48 × 10−7 mol/L) of baicalin with the lowest detection limit of 4.81 × 10−9 mol/L (S/N = 3) when it is used for the detection of baicalin in complex samples. This method provides a new approach for the rapid and sensitive detection of baicalin in complex samples. The application of electrochemical analysis techniques to the instant monitoring of active or indicator components in the materials of traditional Chinese medicine (TCM) and their preparations is expected to provide a sensitive, rapid, and reliable monitoring and analysis technique for the quality control of TCM and their products throughout their life cycle.
期刊介绍：
The Journal of Solid State Electrochemistry is devoted to all aspects of solid-state chemistry and solid-state physics in electrochemistry.
The Journal of Solid State Electrochemistry publishes papers on all aspects of electrochemistry of solid compounds, including experimental and theoretical, basic and applied work. It equally publishes papers on the thermodynamics and kinetics of electrochemical reactions if at least one actively participating phase is solid. Also of interest are articles on the transport of ions and electrons in solids whenever these processes are relevant to electrochemical reactions and on the use of solid-state electrochemical reactions in the analysis of solids and their surfaces.
The journal covers solid-state electrochemistry and focusses on the following fields: mechanisms of solid-state electrochemical reactions, semiconductor electrochemistry, electrochemical batteries, accumulators and fuel cells, electrochemical mineral leaching, galvanic metal plating, electrochemical potential memory devices, solid-state electrochemical sensors, ion and electron transport in solid materials and polymers, electrocatalysis, photoelectrochemistry, corrosion of solid materials, solid-state electroanalysis, electrochemical machining of materials, electrochromism and electrochromic devices, new electrochemical solid-state synthesis.
The Journal of Solid State Electrochemistry makes the professional in research and industry aware of this swift progress and its importance for future developments and success in the above-mentioned fields.
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