碳青霉烯酶的快速鉴定及头孢他啶-阿维巴坦与氨曲南在广泛耐药革兰氏阴性病原体中的体外协同试验：建立前景领域

IF 1.4 4区医学 Q4 IMMUNOLOGY

Indian Journal of Medical Microbiology Pub Date : 2025-04-09 DOI:10.1016/j.ijmmb.2025.100834

Debasish Biswal , Maitrayee Narayan , Sarita Mohapatra , Hitender Gautam , Benu Dhawan , Bimal Kumar Das , Virinder Kumar Bansal , Naveet Wig , Seema Sood

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引用次数: 0

摘要

本研究采用圆盘堆积法评价头孢他啶-阿维巴坦（CZA）单用及与氨曲南（ATM）联用对50株广泛耐药（XDR）革兰氏阴性菌（GNB）的疗效。新德里金属- β -内酰胺酶（NDM）是主要的碳青霉烯酶，在50%的分离株中检测到协同作用。CZA-ATM组合在40%的分离株中显示出协同作用，75%接受该组合的患者实现了微生物清除。这种简单、快速的协同测试方法可以在资源有限的情况下指导有效的治疗决策。

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“Rapid identification of carbapenemases and in vitro synergy testing of ceftazidime-avibactam with aztreonam in extensively drug-resistant Gram-negative pathogens: Establishing the realm of promise”

This study evaluated the effectiveness of ceftazidime-avibactam (CZA) alone and in combination with aztreonam (ATM) against 50 extensively drug-resistant (XDR) Gram-negative bacteria (GNB) isolates using disk stacking method. New Delhi metallo-beta-lactamase (NDM) was the predominant carbapenemase, detected in 50% of isolates showing synergy. The CZA-ATM combination demonstrated synergy in 40% of isolates, with 75% of patients receiving this combination achieving microbiological clearance. This simple, rapid synergy testing method can guide effective therapeutic decisions in resource-limited settings.

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来源期刊

Indian Journal of Medical Microbiology IMMUNOLOGY-

CiteScore

2.20

自引率

0.00%

发文量

154

审稿时长

73 days

期刊介绍： Manuscripts of high standard in the form of original research, multicentric studies, meta analysis, are accepted. Current reports can be submitted as brief communications. Case reports must include review of current literature, clinical details, outcome and follow up. Letters to the editor must be a comment on or pertain to a manuscript already published in the IJMM or in relation to preliminary communication of a larger study. Review articles, Special Articles or Guest Editorials are accepted on invitation.