一氧化氮与实验性自身免疫性脑脊髓炎综述

IF 2.5 4区医学 Q3 IMMUNOLOGY

Journal of neuroimmunology Pub Date : 2025-04-02 DOI:10.1016/j.jneuroim.2025.578586

Maria Staykova, Anne Bruestle

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引用次数: 0

摘要

在不同品系和性别的啮齿动物中，用完全弗氏佐剂（CFA）中的神经抗原免疫可导致从严重的实验性自身免疫性脑脊髓炎（EAE）到无EAE的一系列结果。当用CFA代替羰基铁时，所有患者都对eae敏感。两种佐剂的区别之一是CFA对eae耐药菌株的诱导型一氧化氮合酶有很强的诱导作用。本文讨论的问题是：1/一氧化氮的过量产生是否可以防止自身免疫的发展？2/在诱导阶段干扰NO水平是否可以使非易感菌株对EAE敏感？3/在诱导期干扰NO水平是否能使易感菌株对EAE产生抗性？这三个问题的答案是肯定的，其中一个原因是no诱导的致脑性T细胞的肌动蛋白极化导致其跨内皮迁移减少。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Nitric oxide and experimental autoimmune encephalomyelitis review

Immunisation with neuroantigen in complete Freund's adjuvant (CFA) results in a range from severe experimental autoimmune encephalomyelitis (EAE) to no EAE in various strains and sexes of rodents. When CFA was substituted for carbonyl iron, all were EAE-susceptible. One of the differences between the two adjuvants was the strong induction of inducible nitric oxide synthase in EAE-resistant strains by CFA.

The questions discussed in this review are:

1/ Could exaggerated production of nitric oxide protect against development of autoimmunity?

2/ Could non-susceptible strains be rendered susceptible to EAE by interfering with NO levels during the inductive phase?

3/ Could susceptible strains be rendered resistant to EAE by interfering with NO levels during the inductive phase?

The answer to the three questions is “yes” and one of the reasons is the NO-induced actin polarization in the encephalitogenic T cells leading to their reduced trans-endothelial migration.

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来源期刊

Journal of neuroimmunology 医学-免疫学

CiteScore

6.10

自引率

3.00%

发文量

154

审稿时长

37 days

期刊介绍： The Journal of Neuroimmunology affords a forum for the publication of works applying immunologic methodology to the furtherance of the neurological sciences. Studies on all branches of the neurosciences, particularly fundamental and applied neurobiology, neurology, neuropathology, neurochemistry, neurovirology, neuroendocrinology, neuromuscular research, neuropharmacology and psychology, which involve either immunologic methodology (e.g. immunocytochemistry) or fundamental immunology (e.g. antibody and lymphocyte assays), are considered for publication.