探讨免疫和甲状腺生物标志物在乳腺癌和桥本甲状腺炎患者中的临床意义

IF 2.5 3区生物学 Q3 REPRODUCTIVE BIOLOGY

Reproductive biology Pub Date : 2025-04-12 DOI:10.1016/j.repbio.2025.101011

Israa Khalaf Aneed , Noori Mohammed Luaibi , Sajid Nader Abdulqader

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引用次数: 0

摘要

乳腺癌合并桥本甲状腺炎（BC-HT）呈现出一种独特的免疫-甲状腺相互作用，目前尚不清楚。本研究探讨BC-HT患者和健康对照者甲状腺功能标志物（TSH、T3、T4）、免疫标志物（CD33、CD44）和甲状腺自身抗体（Anti-TPO、Anti-Tg）之间的关系。正态性检验证实了数据的非参数分布，需要采用Mann-Whitney U检验进行组间比较。与对照组相比，BC-HT患者表现出TSH、CD33、Anti-TPO和Anti-Tg水平显著升高，同时T3和T4水平降低，提示甲状腺功能障碍。Spearman的相关分析显示，对照组TSH和T3/T4之间存在很强的负相关，而BC-HT中不存在这种负相关，表明正常的甲状腺反馈机制受到破坏。此外，CD33和CD44与甲状腺激素的相关性在对照组中很明显，但在BC-HT中不存在，这突出了免疫-甲状腺相互作用的改变。ROC分析显示TSH、Anti-Tg和Anti-TPO具有较高的诊断效能，灵敏度超过0.75，而CD33和CD44的诊断效用有限。这些发现提示BC-HT患者存在明显的免疫-甲状腺失调，并强调了甲状腺特异性标志物在疾病分层中的潜力。未来的研究应侧重于纵向研究和机制调查，以进一步描述免疫标志物在甲状腺自身免疫背景下乳腺癌病理生理中的作用。

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Investigating the clinical significance of immune and thyroid biomarkers in women with breast cancer and Hashimoto's thyroiditis

Breast cancer with Hashimoto’s thyroiditis (BC-HT) presents a unique immuno-thyroid interplay that remains poorly understood. This study investigates the relationships between thyroid function markers (TSH, T3, T4), immune markers (CD33, CD44), and thyroid autoantibodies (Anti-TPO, Anti-Tg) in BC-HT patients and healthy controls. Normality testing confirmed non-parametric data distribution, necessitating Mann-Whitney U tests for group comparisons. BC-HT patients exhibited significantly elevated TSH, CD33, Anti-TPO, and Anti-Tg levels, alongside reduced T3 and T4, compared to controls, indicating thyroid dysfunction. Spearman’s correlation analysis revealed strong negative correlations between TSH and T3/T4 in controls, which were lost in BC-HT, suggesting disruption of normal thyroid feedback mechanisms. Additionally, CD33 and CD44 correlations with thyroid hormones were evident in controls but absent in BC-HT, highlighting altered immune-thyroid interactions. ROC analysis demonstrated high diagnostic performance for TSH, Anti-Tg, and Anti-TPO, with sensitivities exceeding 0.75, whereas CD33 and CD44 showed limited diagnostic utility. These findings suggest a distinct immuno-thyroid dysregulation in BC-HT patients and highlight the potential of thyroid-specific markers for disease stratification. Future research should focus on longitudinal studies and mechanistic investigations to further delineate the role of immune markers in breast cancer pathophysiology within the context of thyroid autoimmunity.

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来源期刊

Reproductive biology 生物-生殖生物学

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

29 days

期刊介绍： An official journal of the Society for Biology of Reproduction and the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn, Poland. Reproductive Biology is an international, peer-reviewed journal covering all aspects of reproduction in vertebrates. The journal invites original research papers, short communications, review articles and commentaries dealing with reproductive physiology, endocrinology, immunology, molecular and cellular biology, receptor studies, animal breeding as well as andrology, embryology, infertility, assisted reproduction and contraception. Papers from both basic and clinical research will be considered.