西尼罗病毒（WNV） 2系在西班牙首次向人类本土传播

IF 4.1 2区医学 Q1 INFECTIOUS DISEASES

One Health Pub Date : 2025-04-11 DOI:10.1016/j.onehlt.2025.101036

Maria Lara , Carlos S. Casimiro-Soriguer , Irene Pedrosa-Corral , Cristina Gómez-Camarasa , Nicola Lorusso , Jose M. Navarro-Marí , Joaquin Dopazo , Javier Perez-Florido , Sara Sanbonmatsu-Gámez

{"title":"西尼罗病毒（WNV） 2系在西班牙首次向人类本土传播","authors":"Maria Lara , Carlos S. Casimiro-Soriguer , Irene Pedrosa-Corral , Cristina Gómez-Camarasa , Nicola Lorusso , Jose M. Navarro-Marí , Joaquin Dopazo , Javier Perez-Florido , Sara Sanbonmatsu-Gámez","doi":"10.1016/j.onehlt.2025.101036","DOIUrl":null,"url":null,"abstract":"<div><div>West Nile Virus (WNV) lineage 2, primarily endemic to parts of Africa and Europe, has recently emerged as a public health concern in new geographic regions. In 2024, the first autochthonous human case of neuroinvasive disease caused by WNV lineage 2 was identified in Andalusia, Southern Spain. Molecular testing and whole-genome sequencing confirmed WNV lineage 2 as the causative agent. Phylogenetic analysis revealed a close relationship with strains circulating in Central Europe, distinct from previous WNV lineage 2 detections in Spain. Concurrently, WNV lineage 2 RNA was detected in an imperial eagle near the case location, suggesting local viral circulation. This case marks a significant shift in WNV epidemiology in Spain, where lineage 1 has historically been dominant. The findings underscore the expanding range of WNV lineage 2 and the necessity for enhanced vector surveillance, genomic monitoring, and strengthened One Health strategies to mitigate future outbreaks and protect public health.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 101036"},"PeriodicalIF":4.1000,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"First autochthonous transmission of West Nile virus (WNV) lineage 2 to humans in Spain\",\"authors\":\"Maria Lara , Carlos S. Casimiro-Soriguer , Irene Pedrosa-Corral , Cristina Gómez-Camarasa , Nicola Lorusso , Jose M. Navarro-Marí , Joaquin Dopazo , Javier Perez-Florido , Sara Sanbonmatsu-Gámez\",\"doi\":\"10.1016/j.onehlt.2025.101036\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>West Nile Virus (WNV) lineage 2, primarily endemic to parts of Africa and Europe, has recently emerged as a public health concern in new geographic regions. In 2024, the first autochthonous human case of neuroinvasive disease caused by WNV lineage 2 was identified in Andalusia, Southern Spain. Molecular testing and whole-genome sequencing confirmed WNV lineage 2 as the causative agent. Phylogenetic analysis revealed a close relationship with strains circulating in Central Europe, distinct from previous WNV lineage 2 detections in Spain. Concurrently, WNV lineage 2 RNA was detected in an imperial eagle near the case location, suggesting local viral circulation. This case marks a significant shift in WNV epidemiology in Spain, where lineage 1 has historically been dominant. The findings underscore the expanding range of WNV lineage 2 and the necessity for enhanced vector surveillance, genomic monitoring, and strengthened One Health strategies to mitigate future outbreaks and protect public health.</div></div>\",\"PeriodicalId\":19577,\"journal\":{\"name\":\"One Health\",\"volume\":\"20 \",\"pages\":\"Article 101036\"},\"PeriodicalIF\":4.1000,\"publicationDate\":\"2025-04-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"One Health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2352771425000722\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"One Health","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2352771425000722","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

摘要

西尼罗河病毒（WNV）2系主要流行于非洲和欧洲部分地区，最近在新的地理区域成为公共卫生问题。2024 年，在西班牙南部的安达卢西亚发现了首例由西尼罗河病毒 2 型引起的神经侵袭性疾病的本地人类病例。分子检测和全基因组测序证实了 WNV 2 型是病原体。系统发育分析表明，该病毒与中欧流行的毒株关系密切，不同于之前在西班牙检测到的 WNV 2 系。同时，在病例发生地附近的一只雄鹰体内检测到了 WNV 2 代 RNA，表明病毒在当地流行。该病例标志着西班牙的 WNV 流行病学发生了重大变化，因为在西班牙，1 系病毒一直占主导地位。研究结果突出表明，WNV 2 型的传播范围正在不断扩大，因此有必要加强病媒监测、基因组监测和 "一体健康 "战略，以减轻未来的疫情爆发并保护公众健康。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

First autochthonous transmission of West Nile virus (WNV) lineage 2 to humans in Spain

West Nile Virus (WNV) lineage 2, primarily endemic to parts of Africa and Europe, has recently emerged as a public health concern in new geographic regions. In 2024, the first autochthonous human case of neuroinvasive disease caused by WNV lineage 2 was identified in Andalusia, Southern Spain. Molecular testing and whole-genome sequencing confirmed WNV lineage 2 as the causative agent. Phylogenetic analysis revealed a close relationship with strains circulating in Central Europe, distinct from previous WNV lineage 2 detections in Spain. Concurrently, WNV lineage 2 RNA was detected in an imperial eagle near the case location, suggesting local viral circulation. This case marks a significant shift in WNV epidemiology in Spain, where lineage 1 has historically been dominant. The findings underscore the expanding range of WNV lineage 2 and the necessity for enhanced vector surveillance, genomic monitoring, and strengthened One Health strategies to mitigate future outbreaks and protect public health.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

One Health Medicine-Infectious Diseases

CiteScore

8.10

自引率

4.00%

发文量

审稿时长

18 weeks

期刊介绍： One Health - a Gold Open Access journal. The mission of One Health is to provide a platform for rapid communication of high quality scientific knowledge on inter- and intra-species pathogen transmission, bringing together leading experts in virology, bacteriology, parasitology, mycology, vectors and vector-borne diseases, tropical health, veterinary sciences, pathology, immunology, food safety, mathematical modelling, epidemiology, public health research and emergency preparedness. As a Gold Open Access journal, a fee is payable on acceptance of the paper. Please see the Guide for Authors for more information. Submissions to the following categories are welcome: Virology, Bacteriology, Parasitology, Mycology, Vectors and vector-borne diseases, Co-infections and co-morbidities, Disease spatial surveillance, Modelling, Tropical Health, Discovery, Ecosystem Health, Public Health.