用于乳腺癌治疗的纳米结构材料通过纳米纤维、纳米网和纳米花增强药物传递

Navya Aggarwal, Shreya Gupta, Shinjini Sen, Tanmay J. Urs, Banashree Bondhopadhyay
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引用次数: 0

摘要

乳腺癌药物输送系统严重依赖传统的辅助制剂给药途径。这些系统已经开发了几十年,以推断出更安全、生物可利用、特异性、选择性和有效的模式。纳米技术为解决这些问题而提出的基于纳米技术的药物传递系统,导致了基于纳米颗粒、脂质体、纳米囊泡、纳米胶囊和类似产品的蓬勃发展。现有系统的改进激发了可生物降解的纳米结构,如纳米纤维、纳米网和纳米花。这些结构提供了更好的机会来提高靶向性、生物利用度和更好的安全性。该平台还有助于负载药物的控释。这篇微型综述探讨了纳米纤维、纳米网和纳米花在乳腺癌治疗中的应用,它们是用于化疗药物输送的新兴纳米结构。纳米纤维模拟天然细胞外基质,可以进行生物降解和肿瘤鉴定。纳米网提供了一个大的药物抗原装载平台。另一方面,可以方便地调节纳米花来控制药物的释放。这些纳米结构提供了创新的解决方案,以克服典型的药物吸收、选择性和肿瘤视线上的递送缺陷。在这篇微型综述中,我们旨在全面介绍这些纳米结构是如何产生的,阐述它们的作用机制以及它们是如何发展乳腺癌药物输送系统的。这项研究优先考虑这些纳米结构,因为它们具有明显的好处,同时也解决了它们在乳腺癌治疗方面的局限性,这些局限性需要进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nanostructured materials for breast cancer therapeutics enhancing drug delivery through nanofibers, nano-mesh, and nanoflowers
Breast cancer drug delivery systems rely heavily on conventional routes of administration through adjuvant formulations. These systems have been under development for decades to deduce safer, bioavailable, specific, selective and efficacious modalities. Nanotechnology based drug delivery systems proposed to solve these issues, have led to a boom in nanoparticle based, liposomal, nanovesicles, nanocapsules, and similar provisions. The improvement of the existing available systems inspired biodegradable nanostructures such as nanofibers, nanomesh and nanoflowers. These structures provide better opportunities to improve targetability, bioavailability, better safety profiles. The platforms additionally facilitate controlled release of the loaded drugs. This minireview explores nanofibers, nanomesh and nanoflowers in breast cancer treatment as emerging nanostructures for delivery of chemotherapeutics. Nanofibers emulate the natural extracellular matrix which can be modified for biodegradability and tumor identification. Nanomesh provide large drug-antigen loading platform with interwoven strands.On the other hand, nanoflowers can be conveniently modulated to control the release of the drug. These nanostructures offer innovative solutions to the typical drawbacks of drug absorption, selectivity and delivery on tumor sight. In this minireview, we aim to comprehensively present how these nanostructures are created, address their mechanism of action and how they are developing the landscape of breast cancer drug delivery systems.The study prioritizes these nanostructures over their conventional counterparts due to their visible benefits while also addressing their limitations which should be further researched upon, for breast cancer therapeutics.
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