意大利孕前和孕期叶酸/叶酸盐使用的流行病学：一项横断面观察研究的结果

IF 2.1 4区医学 Q2 OBSTETRICS & GYNECOLOGY

European journal of obstetrics, gynecology, and reproductive biology Pub Date : 2025-04-07 DOI:10.1016/j.ejogrb.2025.113967

Fabio Parazzini , Paola Agnese Mauri , Giovanna Esposito , Annalisa Agangi , Sara Iannantuoni , Mariarosaria Motta , Chiara Murolo , Francesca Navarra , Ilenia Nobile , Claudio Santangelo , Laura Sarno , Luigi Stradella , Cristina Stradella , Roberta Ventrone , Irene Verdoscia , Francesco Tarsitano , Giuseppe Maria Maruotti

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引用次数: 0

摘要

目的孕前补充叶酸是降低神经管缺陷和不良妊娠结局的重要预防措施。为了估计在意大利孕前和怀孕期间叶酸/叶酸使用的频率和决定因素，我们进行了一项横断面观察研究。研究设计研究期间在参与医院随机选择的日期分娩的18岁或以上的妇女符合研究条件。在获得知情同意后，这些妇女在分娩后住院期间由一名合格的采访者进行访谈。调查问卷包括一般信息，如年龄、教育程度、以前的怀孕和产妇疾病。此外，调查问卷还专门收集了有关孕前和怀孕期间叶酸使用情况的信息。结果共访谈958名女性。5.4% （95%CI: 4.1-7.1）的参与者在怀孕前三个月或更长时间内使用叶酸/叶酸，34.3% （95%CI: 31.3-37.5）从怀孕前三个月或更长时间到怀孕结束，6.1% （95%CI: 4.6-7.8）从怀孕到怀孕结束，47.3% （95%CI: 44.1-50.5）从怀孕到怀孕结束，2.4% （95%CI: 1.5-3.6）仅在怀孕前三个月之后。在老年妇女中，孕前用药比年轻妇女更常见。同样，试图怀孕的女性比没有怀孕的女性更有可能在孕前服用叶酸。结论本研究强调需要开展宣传活动，以促进先期使用叶酸/叶酸预防神经管缺陷。

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Epidemiology of folic acid/folates use in the preconceptional period and during pregnancy in Italy: results from a cross-sectional observational study

Objective

Preconceptional folic acid/folates supplementation is an important preventive measure to reduce the risk of neural tube defects and adverse pregnancy outcomes. To provide an estimate of the frequency and the determinants of folic acid/folates use in the preconceptional period and during pregnancy in Italy, we conducted a cross-sectional observational study.

Study design

Women aged 18 years or older who gave birth on randomly selected days in the participating hospitals during the study period were eligible for the study. After obtaining informed consent, the women were interviewed by a qualified interviewer during their stay in hospital after giving birth. The questionnaire included general information such as age, education, previous pregnancies, and maternal diseases. Furthermore, the questionnaire specifically collected information on the use of folic acid/folates in the preconceptional period and during pregnancy.

Results

A total of 958 women were interviewed. The 5.4% (95%CI: 4.1–7.1) of participants declared to use folic acid/folates from three months or more before conception to the end of the first trimester, 34.3% (95%CI: 31.3–37.5) from three months or more before conception to the end of pregnancy, 6.1% (95%CI: 4.6–7.8) from conception to the end of first trimester, 47.3% (95%CI: 44.1–50.5) from conception to the end of pregnancy, and 2.4% (95%CI: 1.5–3.6) only after the first trimester of pregnancy. Preconceptional use was more common in older women than in younger ones. Similarly, women who were trying to get pregnant were more likely to report preconceptional use of folic acid than women who were not.

Conclusion

This study highlights the need for information campaigns to promote the preconceptional use of folic acid/folates for the prevention of neural tube defects.

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来源期刊

European journal of obstetrics, gynecology, and reproductive biology 医学-妇产科学

CiteScore

4.60

自引率

3.80%

发文量

898

审稿时长

8.3 weeks

期刊介绍： The European Journal of Obstetrics & Gynecology and Reproductive Biology is the leading general clinical journal covering the continent. It publishes peer reviewed original research articles, as well as a wide range of news, book reviews, biographical, historical and educational articles and a lively correspondence section. Fields covered include obstetrics, prenatal diagnosis, maternal-fetal medicine, perinatology, general gynecology, gynecologic oncology, uro-gynecology, reproductive medicine, infertility, reproductive endocrinology, sexual medicine and reproductive ethics. The European Journal of Obstetrics & Gynecology and Reproductive Biology provides a forum for scientific and clinical professional communication in obstetrics and gynecology throughout Europe and the world.