异常泛素化导致肝癌：ADRM1-ΔEx9- FBXW7的联系

IF 26.8 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Journal of Hepatology Pub Date : 2025-04-11 DOI:10.1016/j.jhep.2025.03.032

Diego F. Calvisi

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引用次数: 0

摘要

利益冲突无需透露肝细胞癌（HCC）约占原发性肝脏肿瘤的85%-90%，是全球第六大常见恶性肿瘤和第三大癌症相关死亡原因。手术切除、肝移植和局部治疗可能治愈早期HCC。然而，晚期HCC患者的预后仍然很差。事实上，尽管引入了不同的全身疗法，如免疫检查点抑制剂和财政支持

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Aberrant ubiquitination causing liver cancer: the ADRM1-ΔEx9- FBXW7 connection

Section snippets

Conflict of interest

Nothing to discloseHepatocellular carcinoma (HCC), accounting for approximately 85%-90% of primary liver tumors, is the sixth most common malignancy and the third cause of cancer- related mortality worldwide. Surgical resection, liver transplantation, and locoregional therapies can potentially cure early-stage HCC. However, the prognosis for patients with advanced HCC is still poor. Indeed, despite the introduction of different, systemic therapies, such as immune checkpoint inhibitors and

Financial support

None

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来源期刊

Journal of Hepatology 医学-胃肠肝病学

CiteScore

46.10

自引率

4.30%

发文量

2325

审稿时长

30 days

期刊介绍： The Journal of Hepatology is the official publication of the European Association for the Study of the Liver (EASL). It is dedicated to presenting clinical and basic research in the field of hepatology through original papers, reviews, case reports, and letters to the Editor. The Journal is published in English and may consider supplements that pass an editorial review.