[18F]三氟化单氟烷基酯的放射性标记氟化合成[18]二氟甲基化烷烃

IF 4.3 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-04-11 DOI:10.1039/d5cc00869g

Yuan-Zhan Han, Peng-Fei Song, Hai-Yang Zhao, Junbin Han, Xingang Zhang

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引用次数: 0

摘要

采用放射性氟化[18F]与三氟化单氟烷基盐结合的方法合成了[18F]-二氟甲基化烷烃。该方法使用[18F]KF/K2.2.2。作为氟源。它具有合成简单、前驱体制备繁琐、RCC和RCY高、官能团耐受性好、无银盐等特点，具有开发新型PET试剂的潜力。

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[18F]Radiolabeling Fluorination of Monofluoroalkyl Triflates for the Synthesis of [18]Difluoromethylated Alkanes

An efficient method for the synthesis of [18F]-difluoromethylated alkanes has been developed by combining [18F]radiofluoride with monofluoroalkyl triflates. This method uses [18F]KF/K2.2.2. as the fluorine source. It features synthetic simplicity without tedious precursor preparation, high RCC and RCY, good functional group tolerance, and is silver salt-free, providing potential for developing new PET agents.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.