环境相关浓度的三氯生诱导斑马鱼的跨代甲状腺激素紊乱

IF 7.6 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Pollution Pub Date : 2025-04-11 DOI:10.1016/j.envpol.2025.126242

Ping Ding , Jiayi Zhang , Xin Li , Pengcheng Ma , Guocheng Hu , Lijuan Zhang , Yunjiang Yu

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引用次数: 0

摘要

为应对2019冠状病毒病（COVID-19）大流行，使用含三氯生（TCS）的消毒剂变得越来越普遍，导致水体生态系统中TCS的含量增加。甲状腺激素（THs）对许多发育和代谢过程至关重要，其结构与TCS相似，使其易于发挥内分泌干扰作用。在这项研究中，我们证明了TCS可以诱导斑马鱼的甲状腺激素中断，并具有跨代后果。将斑马鱼胚胎暴露于环境相关浓度的TCS（0、1、3和10 μg/L）中30、60和180天。TCS在斑马鱼体内长时间积累，导致TH水平显著的剂量依赖性改变。此外，TCS显著干扰了P0-F1代甲状腺轴相关基因的表达。分子对接进一步证实，TCS通过与甲状腺球蛋白（TG）潜在的强相互作用诱导甲状腺跨代效应，干扰甲状腺球蛋白的正常生理功能。这些发现表明，环境相关浓度的TCS可以通过破坏三氯甲烷而产生生态有害影响。建议在未来的消毒产品中推广或替代抗菌药物之前，对TCS进行严格的生态评估。

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Transgenerational thyroid hormone disruption in zebrafish induced by environmentally relevant concentrations of triclosan

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Transgenerational thyroid hormone disruption in zebrafish induced by environmentally relevant concentrations of triclosan

The use of triclosan (TCS)-containing disinfectants has become increasingly prevalent in response to the COVID-19 pandemic, leading to a heightened presence of TCS in aquatic ecosystems. Thyroid hormones (THs), which are essential for numerous developmental and metabolic processes, are structurally similar to TCS, rendering it prone to exert endocrine-disrupting effects. In this study, we demonstrate that TCS can induce thyroid hormone disruption in zebrafish, with transgenerational consequences. Zebrafish embryos were exposed to environmentally relevant concentrations of TCS (0, 1, 3, and 10 μg/L) for 30, 60, and 180 days. TCS accumulated in zebrafish over an extended period, causing significant, dose-dependent alterations in TH levels. Furthermore, TCS significantly thereby interfered with the expression of thyroid axis-related genes in the P0-F1 generations. Molecular docking further confirmed that TCS induces transgenerational thyroid effects through potentially strong interactions with thyroglobulin (TG), interfering with the normal physiological function of THs. These findings suggest that TCS at environmentally relevant concentrations can exert ecologically harmful effects by disrupting THs. A rigorous ecological assessment of TCS is recommended before promoting or substituting antimicrobial agents in future disinfection products.

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来源期刊

Environmental Pollution 环境科学-环境科学

CiteScore

16.00

自引率

6.70%

发文量

2082

审稿时长

2.9 months

期刊介绍： Environmental Pollution is an international peer-reviewed journal that publishes high-quality research papers and review articles covering all aspects of environmental pollution and its impacts on ecosystems and human health. Subject areas include, but are not limited to: • Sources and occurrences of pollutants that are clearly defined and measured in environmental compartments, food and food-related items, and human bodies; • Interlinks between contaminant exposure and biological, ecological, and human health effects, including those of climate change; • Contaminants of emerging concerns (including but not limited to antibiotic resistant microorganisms or genes, microplastics/nanoplastics, electronic wastes, light, and noise) and/or their biological, ecological, or human health effects; • Laboratory and field studies on the remediation/mitigation of environmental pollution via new techniques and with clear links to biological, ecological, or human health effects; • Modeling of pollution processes, patterns, or trends that is of clear environmental and/or human health interest; • New techniques that measure and examine environmental occurrences, transport, behavior, and effects of pollutants within the environment or the laboratory, provided that they can be clearly used to address problems within regional or global environmental compartments.