Thomas D. J. Walker, Jessica P. Morris, Leonie Unterholzner
{"title":"转录应激通过IL-1α的释放引起炎症反应","authors":"Thomas D. J. Walker, Jessica P. Morris, Leonie Unterholzner","doi":"10.1038/s41594-025-01525-5","DOIUrl":null,"url":null,"abstract":"DNA damage can be sensed as a danger signal by the innate immune system. Bournique et al. show that the transcription stress caused by DNA lesions can also initiate inflammation by causing the direct release of cytokine IL-1α, which then drives NF-κB activation in neighboring cells.","PeriodicalId":18822,"journal":{"name":"Nature structural & molecular biology","volume":"37 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Transcription stress causes an inflammatory response via release of IL-1α\",\"authors\":\"Thomas D. J. Walker, Jessica P. Morris, Leonie Unterholzner\",\"doi\":\"10.1038/s41594-025-01525-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"DNA damage can be sensed as a danger signal by the innate immune system. Bournique et al. show that the transcription stress caused by DNA lesions can also initiate inflammation by causing the direct release of cytokine IL-1α, which then drives NF-κB activation in neighboring cells.\",\"PeriodicalId\":18822,\"journal\":{\"name\":\"Nature structural & molecular biology\",\"volume\":\"37 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-04-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature structural & molecular biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1038/s41594-025-01525-5\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature structural & molecular biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s41594-025-01525-5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Transcription stress causes an inflammatory response via release of IL-1α
DNA damage can be sensed as a danger signal by the innate immune system. Bournique et al. show that the transcription stress caused by DNA lesions can also initiate inflammation by causing the direct release of cytokine IL-1α, which then drives NF-κB activation in neighboring cells.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
