Electrochemical detection of Paracetamol based on CoO/Co3O4/NC nanocomposites derived from COFs

Acetaminophen (APAP), also known as paracetamol, is a widely used analgesic and antipyretic, but its metabolites are toxic and can cause liver damage when used in excess. Rapid detection of APAP is essential, and conventional methods such as HPLC and GC are expensive and complex. To this purpose, we successfully prepared CoO/Co3O4/NC porous carbon composites with large specific surface area, homogeneous pore structure, and abundant adsorption active sites as electrochemical sensors for the rapid, simple, and inexpensive detection of acetaminophen. The CoO/Co3O4/NC porous carbon composites were prepared by doping Co2+ and calcining, and a large number of N and O metal chelate sites in COFTZT-DVA could coordinate with Co2+, which effectively suppressed the aggregation phenomenon of CoO/Co3O4 in the composites, and realized the uniform dispersion of Co2+. This composite material exhibits both excellent stability and catalytic performance. The experimental results showed that the sensor had an extremely low detection limit (0.79 μM) and a wide linear response range (2.5 μM-423 μM). This study provides a new strategy for the preparation of high-performance paracetamol sensors.