1-杂芳基苯并三唑银化合物抗菌活性的研究

IF 4.6 3区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
RSC Advances Pub Date : 2025-04-11 DOI:10.1039/D5RA01072A
Ahmed Elzein, Ghadah Abdullah S. Al Jomeh, Graham J. Tizzard, Simon J. Coles, Christina N. Banti, Sotiris K. Hadjikakou and George E. Kostakis
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引用次数: 0

摘要

以不同的N,N ' -双齿1-杂芳基苯并三唑配体为原料合成了5个(1-5)Ag(I)化合物,并利用SXRD、IR、UV-Vis、元素分析、ESI-MS和NMR对其进行了表征。配体和反阴离子的变化产生了不同的结构和形态。在DMSO中进行的微摩尔水平的初步抗菌测试表明,只有基于1-(2-吡啶基)苯并三唑和三氟酸阴离子的化合物2表现出有趣的抗菌性能,从而标志着在药物无机化学中引入了一类新的Ag(I)化合物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Investigating the antimicrobial activity of 1-heteroaryl benzotriazole silver compounds†

Investigating the antimicrobial activity of 1-heteroaryl benzotriazole silver compounds†

Five (1–5) Ag(I) compounds, derived from different N,N′-bidentate 1-heteroaryl benzotriazole ligands, were synthesised and characterised using SXRD, IR, UV-Vis, elemental analysis, ESI-MS, and NMR. Variations in ligands and counter-anions produced distinct structures and morphologies. Preliminary antimicrobial testing at the micromolar level, in DMSO, revealed that only compound 2, based on 1-(2-pyridyl)benzotriazole and triflate anion, exhibited interesting antimicrobial properties, thus marking the introduction of a new class of Ag(I) compounds in medicinal inorganic chemistry.

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来源期刊
RSC Advances
RSC Advances chemical sciences-
CiteScore
7.50
自引率
2.60%
发文量
3116
审稿时长
1.6 months
期刊介绍: An international, peer-reviewed journal covering all of the chemical sciences, including multidisciplinary and emerging areas. RSC Advances is a gold open access journal allowing researchers free access to research articles, and offering an affordable open access publishing option for authors around the world.
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