吡唑啉在牙周和种植周疾病中的作用及其意义：一项系统综述

IF 2.2 4区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Archives of oral biology Pub Date : 2025-04-07 DOI:10.1016/j.archoralbio.2025.106256

Mario Alberto Alarcón-Sánchez , Sarah Monserrat Lomelí-Martínez , Ruth Rodríguez-Montaño , Julieta Sarai Becerra-Ruiz , Cristina Hermila Martínez-Bugarin , Seyed Ali Mosaddad , Artak Heboyan

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引用次数: 0

摘要

目的本系统综述旨在探讨 Azurocidin（Azu）在牙周和种植体周围疾病发病机制中的作用及其作为炎症生物标志物的潜在用途：1991年10月10日至2024年7月15日期间的PubMed、Google Scholar、ScienceDirect和Scopus。研究选择和数据提取均以盲法独立进行。乔安娜-布里格斯研究所（JBI）工具用于评估横断面文章的质量，纽卡斯尔-渥太华量表用于评估队列研究。这些研究包括 462 名参与者：其中，156 人的牙齿和种植体健康，306 人患有牙龈炎、牙周炎、根尖牙周炎、种植体周围粘膜炎和种植体周围炎等牙周疾病。共分析了 1313 份样本（163 份唾液样本、118 份 PICF 样本、1003 份 GCF 样本、11 份牙龈组织样本和 18 份感染根管样本）。酶联免疫吸附法（ELISA）是最常用的氮杂环胺分析方法（66.6%），其次是液相色谱-质谱联用仪（LC-MS/MS）（33.3%）、nLC-MS/MS（11.1%）和免疫印迹法（Western Blot）（11.1%）。与牙周健康者相比，牙周炎患者的 Azu 水平持续升高。尽管在牙周炎中观察到阿祖水平升高，但由于数据有限且不一致，其诊断价值仍不明确。

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The role of azurocidin and its implications in periodontal and peri-implant disease: A systematic review

Objectives

This systematic review aimed to explore the role of Azurocidin (Azu) in the pathogenesis of periodontal and peri-implant disease and its potential use as an inflammatory biomarker.

Materials and methods

Four electronic databases were used for study identification: PubMed, Google Scholar, ScienceDirect, and Scopus from Oct 10, 1991 to Jul 15, 2024. Study selection and data extraction were performed in a blinded and independent manner. The Joanna Briggs Institute (JBI) tool was used to assess the quality of cross-sectional articles, and the Newcastle-Ottawa scale was used to assess cohort studies.

Results

Out of 222 identified articles, nine studies met the inclusion criteria. These studies included 462 participants: 156 with healthy teeth and implants and 306 with periodontal conditions such as gingivitis, periodontitis, apical periodontitis, peri-implant mucositis, and peri-implantitis. A total of 1313 samples were analyzed (163 saliva, 118 PICF, 1003 GCF, 11 gingival tissue, and 18 infected root canals). ELISA was the most common method for azurocidin analysis (66.6 %), followed by LC-MS/MS (33.3 %), nLC-MS/MS (11.1 %), and Western Blot (11.1 %). Azu levels were consistently elevated in individuals with periodontitis compared to periodontally healthy subjects.

Conclusions

Azu may contribute to the inflammatory processes in periodontal and peri-implant diseases. Although elevated levels are observed in periodontitis, its diagnostic value remains unclear due to limited and heterogeneous data.

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来源期刊

Archives of oral biology 医学-牙科与口腔外科

CiteScore

5.10

自引率

3.30%

发文量

177

审稿时长

26 days

期刊介绍： Archives of Oral Biology is an international journal which aims to publish papers of the highest scientific quality in the oral and craniofacial sciences. The journal is particularly interested in research which advances knowledge in the mechanisms of craniofacial development and disease, including: Cell and molecular biology Molecular genetics Immunology Pathogenesis Cellular microbiology Embryology Syndromology Forensic dentistry