从海洋来源的真菌Microascus sp. SCSIO 41821中分离出两种具有c环重排麦角苷骨架的5,6-seco-9,10-seco类固醇A和B

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-04-07 DOI:10.1016/j.fitote.2025.106537

Yu-Qian Tang , Fei-Hua Yao , Lian-Xiang Luo , Yi-Han Wu , Shu-Hua Qi

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引用次数: 0

摘要

从海洋来源的真菌菌株Microascus sp. SCSIO 41821中分离到2个未描述的甾体化合物，微ascusteroids A和B(1和2)，以及4个已知化合物（3-6）。通过广泛的光谱分析确定了1和2的结构，并通过电子圆二色（ECD）光谱的量子化学计算确定了它们的绝对构型。特别地，化合物1和2是罕见的5,6-seco-9,10-seco甾体，具有c环重排麦角甾骨架。此外，1和2对脂多糖诱导的RAW 264.7细胞产生一氧化氮表现出中等抑制活性，对PTP1B表现出温和的酶抑制活性，对人类癌细胞株H1975和HepG2表现出细胞毒性。

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Microascusteroids A and B, two 5,6-seco-9,10-seco steroids with a C-ring rearranged ergostane skeleton from the marine-derived fungus Microascus sp. SCSIO 41821

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Microascusteroids A and B, two 5,6-seco-9,10-seco steroids with a C-ring rearranged ergostane skeleton from the marine-derived fungus Microascus sp. SCSIO 41821

Two undescribed steroids, microascusteroids A and B (1 and 2), together with four known compounds (3–6) were isolated from the marine-derived fungal strain Microascus sp. SCSIO 41821. The structures of 1 and 2 were determined by extensive spectroscopic analysis, and their absolute configurations were established by quantum chemical calculations of electronic circular dichroism (ECD) spectra. Specially, compounds 1 and 2 were unusual 5,6-seco-9,10-seco steroids with a C-ring rearranged ergostane skeleton. In addition, 1 and 2 showed medium inhibition activity against lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells and displayed mild enzyme inhibitory activity against PTP1B and cytotoxicity against human cancer cell lines H1975 and HepG2.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.