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IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-04-07 DOI:10.1016/j.fitote.2025.106521

Marina dos Santos Barreto , Ronaldy Santana Santos , Jessiane Bispo de Souza , Júlia Santana Lisboa , Pamela Chaves de Jesus , Deise Maria Rego Rodrigues Silva , Pedro Henrique Macedo Moura , Wesley Lisboa de Jesus , Eloia Emanuelly Dias Silva , Rajiv Gandhi Gopalsamy , Lucas Alves da Mota Santana , Lysandro Pinto Borges , Adriana Gibara Guimarães

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引用次数: 0

摘要

高血糖的特点是血糖水平高且得不到补偿，从而导致糖尿病（DM）。太阳花提取物可能具有降血糖特性，可用作糖尿病及其并发症的辅助疗法。本综述评估了临床前和临床研究中太阳花属植物提取物对降低血糖的作用。研究中分离出的化合物或与提取物相关的其他化合物并未测量血糖谱；综述文章以及体外和体内文章均被排除在外。综述遵循了系统综述和荟萃分析首选报告项目（PRISMA）协议，并使用实验室动物实验系统综述中心（SYRCLE）工具对临床前研究进行偏倚风险（RoB）评估。共纳入 14 项研究，包括 12 项临床前研究和 1 项临床研究。对临床前研究进行了荟萃分析，结果表明在降低血糖和 HbA1c 水平方面效果显著。对临床研究的定性分析也显示出降低血糖的效果。菊粉和绿原酸（CGA）分别在 Helianthus tuberosus L. 和 Helianthus annuus L. 中被确定为可能产生这些药理作用的化合物。太阳花的提取物可有效改善血糖状况，从而控制糖尿病并将其并发症降至最低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The role of the Helianthus genus in Hyperglycemia: A systematic review with meta-analysis

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The role of the Helianthus genus in Hyperglycemia: A systematic review with meta-analysis

Hyperglycemia is characterized by high and uncompensated glucose levels, leading to diabetes mellitus (DM). Helianthus species extracts may have hypoglycemic properties and can be used as a complementary therapy for diabetes and its complications. This review evaluates the effects of extracts from Helianthus species on glycemia reduction in preclinical and clinical studies. Studies that isolated compounds or other associated compounds with the extract did not measure the glycemic profile; review articles and in vitro and ex vivo articles were excluded. The review followed the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) protocols, and the systematic review center for laboratory animal experimentation (SYRCLE) tool was used for preclinical studies risk-of-bias (RoB) assessment. 14 studies, including 12 preclinical and 1 clinical study, were included. A meta-analysis was applied to preclinical studies and showed a significant effect in reducing glycemia and HbA1c levels. Qualitative analysis of the clinical study has also shown a reduction in glycemia. Inulin and chlorogenic acid (CGA) were identified in Helianthus tuberosus L. and Helianthus annuus L., respectively, as compounds possibly responsible for these pharmacological effects. Extracts of the Helianthus species have been effective in improving the glycemic profile, making it possible to control DM and minimize its complications.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.