有效的草药提取物减轻化疗诱导的骨髓抑制：一项系统回顾和荟萃分析

IF 6.7 1区医学 Q1 CHEMISTRY, MEDICINAL

Phytomedicine Pub Date : 2025-03-24 DOI:10.1016/j.phymed.2025.156659

De-Hui Wang, Xiao-Ni Ma, Yan Wang, Yi-Xiao Wei, Po Hu, Yang Pan

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引用次数: 0

摘要

背景骨髓抑制是化疗的一个主要副作用。它损害骨髓的造血功能，降低免疫力，增加无法控制的出血。晚期骨髓抑制甚至会迫使患者停止治疗。本研究旨在评估中草药提取物对化疗引起的骨髓抑制的影响，为其减轻骨髓抑制的潜力提供证据，并探讨其进一步临床应用的前景。方法我们在六个中英文数据库中进行了系统检索，筛选出符合纳入标准的研究。通过对动物实验的系统回顾，我们提取并分析了评估中草药提取物对骨髓抑制作用的研究数据，提供了适当的对照组进行比较，并报告了与骨髓抑制相关的主要结果。结果综合分析表明，草药提取物对骨髓抑制有显著的保护作用。草药提取物治疗能提高血红蛋白、白细胞、血小板和粒细胞的水平，同时还能增强免疫力，这可能是缓解化疗引起的骨髓抑制的有效方法。结论这篇系统综述和荟萃分析强调了草药提取物在缓解化疗引起的骨髓抑制中的重要作用，为今后的临床研究奠定了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Validated herbal extracts for alleviating chemotherapy-induced myelosuppression: A systematic review and meta-analysis

查看原文本刊更多论文

Validated herbal extracts for alleviating chemotherapy-induced myelosuppression: A systematic review and meta-analysis

Background

Myelosuppression is a major side effect of chemotherapy. It impairs hematopoietic function of bone marrow, decreases immunity, increases uncontrolled bleeding. Advanced myelosuppression even forces discontinuation of treatment. The agents that reduce myelosuppression can promote outcomes of clinical chemotherapy, and herbal extracts show the effects.

Purpose

This study aims to evaluate the effects of herbal extracts on chemotherapy-induced myelosuppression, providing evidence of their potential in mitigating myelosuppression and exploring their prospects for further clinical application.

Methods

We conducted a systematic search in six English and Chinese databases and screened studies that met the inclusion criteria. Through a systematic review of animal experiments, data were extracted and analyzed from studies that evaluated the effect of herbal extracts on myelosuppression, provided appropriate control groups for comparison, and reported key outcomes related to myelosuppression. We screened 6169 articles and ultimately selected 95 experimental studies for final analysis.

Results

The comprehensive analysis indicates that herbal extracts have a significant protective effect on myelosuppression. Herbal extracts treatment increases levels of hemoglobin, white blood cells, platelets, and granulocytes, while also enhancing immunity, which may be an effective way to alleviate chemotherapy-induced myelosuppression.

Conclusion

This systematic review and meta-analysis underscore the significant role of herbal extracts in alleviating chemotherapy-induced myelosuppression, laying a foundation for future clinical.

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来源期刊

Phytomedicine 医学-药学

CiteScore

10.30

自引率

5.10%

发文量

670

审稿时长

91 days

期刊介绍： Phytomedicine is a therapy-oriented journal that publishes innovative studies on the efficacy, safety, quality, and mechanisms of action of specified plant extracts, phytopharmaceuticals, and their isolated constituents. This includes clinical, pharmacological, pharmacokinetic, and toxicological studies of herbal medicinal products, preparations, and purified compounds with defined and consistent quality, ensuring reproducible pharmacological activity. Founded in 1994, Phytomedicine aims to focus and stimulate research in this field and establish internationally accepted scientific standards for pharmacological studies, proof of clinical efficacy, and safety of phytomedicines.