妊娠期间与颈动脉内膜-中膜厚度相关的母体和心血管因素：一项前瞻性队列研究

IF 2.1 4区医学 Q2 OBSTETRICS & GYNECOLOGY

European journal of obstetrics, gynecology, and reproductive biology Pub Date : 2025-03-29 DOI:10.1016/j.ejogrb.2025.113943

Maia Brik , Miguel Sánchez-Polán , Alba Farràs , Alina Hernández-Fleury , Joaquin Temprado , Inés Calero , Teresa Higueras , Cristina Silva , Dingfeng Zhang , Elena Carreras , Ruben Barakat

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引用次数: 0

摘要

目的心血管疾病仍然是全球女性最重要的死因。颈动脉内膜中层厚度（CIMT）是心血管疾病的一个著名指标。该研究旨在确定妊娠期 CIMT 测量值与心血管疾病风险因素之间的关联。51 名妇女的 CIMT 测量采用 B 型超声波。结果20-22周（0.513 ± 0.0067）、28-30周（0.504 ± 0.077）和33-36周（0.499 ± 0.059）的CIMT（毫米）正常参考值（平均值 ± sd）。产妇年龄与 CIMT 相关（Rho Spearman = 0.392，p = 0.016）。然而，所研究的其他变量，如体重增加、SBP、DBP、子宫动脉多普勒、HbA1c、血脂概况、感知压力（PSS）和焦虑症状（STAI）与 CIMT 测量值无相关性。活动参与者与非活动参与者的 CIMT 值相似（0.540 ± 0.069 vs. 0.489 ± 0.054 mm，P = 0.053）。结论在血压正常的孕妇中，CIMT 与孕妇年龄有关，但在整个孕期保持稳定，不受孕期各种心血管风险因素的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Maternal and cardiovascular factors related to carotid intima-media thickness during pregnancy: A prospective cohort study

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Maternal and cardiovascular factors related to carotid intima-media thickness during pregnancy: A prospective cohort study

Objective

Cardiovascular disease continues to be the most important cause of death among women worldwide. Carotid intima-media thickness (CIMT) is a well-known indicator of cardiovascular disease. The study aims to establish associations between CIMT measurements and cardiovascular disease risk factors in pregnancy.

Methods

A prospective observational study including normotensive pregnant women. CIMT was measured by mode B-ultrasound in 51 women. Baseline characteristics, weight gain, SBP, DBP, uterine artery Doppler, HbA1c, lipid profile, perceived stress (PSS), anxiety symptoms (STAI) and the level of physical activity during pregnancy were recorded.

Results

Normal reference values (mean ± sd) for CIMT (mm) were described for 20–22 weeks (0.513 ± 0.0067), 28–30 weeks (0.504 ± 0.077) and 33–36 weeks (0.499 ± 0.059). Maternal age was correlated to CIMT (Rho Spearman = 0.392, p = 0.016). However, other variables studied such as weight gain, SBP, DBP, uterine artery Doppler, HbA1c, lipid profile, perceived stress (PSS), and anxiety symptoms (STAI) showed no correlation with CIMT measurements. CIMT was similar in active vs non-active participants (0.540 ± 0.069 vs. 0.489 ± 0.054 mm, p = 0.053). CIMT measurements did not change with gestational age (p = 0.751).

Conclusions

Among normotensive pregnant individuals, CIMT is associated with maternal age but remains stable across gestational age and unaffected by various cardiovascular risk factors during pregnancy.

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来源期刊

European journal of obstetrics, gynecology, and reproductive biology 医学-妇产科学

CiteScore

4.60

自引率

3.80%

发文量

898

审稿时长

8.3 weeks

期刊介绍： The European Journal of Obstetrics & Gynecology and Reproductive Biology is the leading general clinical journal covering the continent. It publishes peer reviewed original research articles, as well as a wide range of news, book reviews, biographical, historical and educational articles and a lively correspondence section. Fields covered include obstetrics, prenatal diagnosis, maternal-fetal medicine, perinatology, general gynecology, gynecologic oncology, uro-gynecology, reproductive medicine, infertility, reproductive endocrinology, sexual medicine and reproductive ethics. The European Journal of Obstetrics & Gynecology and Reproductive Biology provides a forum for scientific and clinical professional communication in obstetrics and gynecology throughout Europe and the world.