减少氧运输如何降低患帕金森病的风险

IF 6.7 1区医学 Q1 NEUROSCIENCES

NPJ Parkinson's Disease Pub Date : 2025-04-10 DOI:10.1038/s41531-025-00929-w

Johannes Burtscher, Daniel Debertin, Martin Kopp, Martin Burtscher, Atbin Djamshidian, Peter Federolf

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引用次数: 0

摘要

吸烟过程中产生的一氧化碳（CO）被认为是帕金森病（PD）的保护因素。在大鼠中，CO水平的增加最近被证明可以诱导缺氧反应样通路的激活。因此，吸烟可以通过挑战氧气运输系统来加强缺氧反应系统，从而增加细胞的弹性。在这里，我们概述了两种新的有希望的治疗PD的方法，低剂量CO吸入和缺氧调节之间的重叠。

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How reducing oxygen-transport may lower the risk of developing Parkinson’s disease

Carbon monoxide (CO) produced during smoking has been proposed to be a protective factor for Parkinson’s disease (PD). In rats, increasing CO levels have recently been shown to induce hypoxic response-like pathway activation. Smoking thus may strengthen the hypoxia response systems by challenging the oxygen transport system, resulting in increased cellular resilience. Here we outline the overlaps between two novel promising approaches against PD, low-dose CO inhalations and hypoxia conditioning.

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来源期刊

NPJ Parkinson's Disease Medicine-Neurology (clinical)

CiteScore

9.80

自引率

5.70%

发文量

156

审稿时长

11 weeks

期刊介绍： npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.