二倍体高阶三维人类基因组分析的无障碍技术

IF 10.1 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2025-04-09 DOI:10.1038/s41594-025-01519-3

引用次数: 0

摘要

我们开发了一种方法，使用比传统方法少得多的数据，将人类单倍型分配染色质相互作用的检测提高了十倍以上。这一进展使几乎完整的二倍体3D基因组图谱成为可能，使研究人员更容易进行高阶分阶段染色质相互作用的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Accessible technology for diploid high-order 3D human genome analysis

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Accessible technology for diploid high-order 3D human genome analysis

We developed a method that improves the detection of haplotype-assigned chromatin interactions in humans by over tenfold, using far less data than traditional methods. This advance enabled an almost complete diploid 3D genome map, making high-order phased chromatin interaction studies more accessible to researchers.

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.