细胞外囊泡mirna分析揭示mirna参与代谢功能障碍相关脂肪变性肝病患者的脂质代谢功能障碍、慢性炎症和肝损伤

IF 6.6 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Alimentary Pharmacology & Therapeutics Pub Date : 2025-04-10 DOI:10.1111/apt.70150

Gian Paolo Caviglia, Elisabetta Casalone, Chiara Rosso, Serena Aneli, Alessandra Allione, Fabrizia Carli, Cristina Grange, Angelo Armandi, Chiara Catalano, Giovanni Birolo, Beatrice Foglia, Davide Giuseppe Ribaldone, Amalia Gastaldelli, Giuseppe Matullo, Elisabetta Bugianesi

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引用次数: 0

摘要

MicroRNAs （miRNAs）是短的非编码寡核苷酸，参与基因表达的转录后调控。我们研究了在代谢功能障碍相关脂肪变性肝病（MASLD）的组织学谱中，循环细胞外囊泡（ev）的miRNome谱与代谢紊乱、循环和肝脏促炎细胞因子以及肝损伤之间的关系。

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Extracellular Vesicles miRNome Profiling Reveals miRNAs Engagement in Dysfunctional Lipid Metabolism, Chronic Inflammation and Liver Damage in Subjects With Metabolic Dysfunction-Associated Steatotic Liver Disease

查看原文本刊更多论文

MicroRNAs (miRNAs) are short non-coding oligonucleotides involved in the post-transcriptional regulation of gene expression. We investigated the association between the miRNome profile of circulating extracellular vesicles (EVs) and metabolic derangements, circulating and hepatic pro-inflammatory cytokines, and liver damage across the histological spectrum of metabolic dysfunction-associated steatotic liver disease (MASLD).

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来源期刊

Alimentary Pharmacology & Therapeutics 医学-胃肠肝病学

CiteScore

15.60

自引率

7.90%

发文量

527

审稿时长

3-6 weeks

期刊介绍： Alimentary Pharmacology & Therapeutics is a global pharmacology journal focused on the impact of drugs on the human gastrointestinal and hepato-biliary systems. It covers a diverse range of topics, often with immediate clinical relevance to its readership.