放疗治疗颅底或头部不能手术的良性软组织肿瘤的远期疗效。

Radiation oncology journal Pub Date : 2025-03-01 Epub Date: 2025-03-10 DOI:10.3857/roj.2024.00493
Joo-Hyun Chung, Hak Jae Kim, Hyun-Cheol Kang, Il Han Kim, Joo Ho Lee
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引用次数: 0

摘要

本研究旨在评价放疗治疗软组织良性肿瘤的远期疗效及并发症。本研究纳入5例行放射治疗的良性软组织肿瘤(2例丛状神经纤维瘤、2例幼年鼻咽血管纤维瘤、1例海绵窦血管瘤)。所有患者至少有10年的随访。中位随访时间为12年(范围10 - 27年)。3例患者在放疗前行不完全切除。辐射剂量为30段54戈瑞或28段50.4戈瑞(每段1.8戈瑞)。每位患者均达到完全缓解(CR)或接近完全缓解。肿瘤体积在随访的前2年内显著减小,并持续缓慢减小至10年;10年后没有观察到肿瘤体积进一步明显减少。1例患者放疗后8年出现左侧下颌骨发育不全。在放射治疗后的几年内,良性软组织肿瘤的体积明显减小。因此,对于不能切除或不完全切除的良性软组织肿瘤,放疗是一种可行的选择,并发症风险最小。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Long-term outcomes of radiotherapy for inoperable benign soft tissue tumors in the skull base or head.

This study aimed to evaluate the long-term efficacy and complication of radiotherapy for benign soft tissue tumors. Five cases of benign soft tissue tumors (two plexiform neurofibromas, two juvenile nasopharyngeal angiofibromas, and one cavernous sinus hemangioma) who underwent radiotherapy were enrolled. All patients had at least 10 years of follow-up. The median follow-up duration was 12 years (range, 10 to 27). Three patients underwent incomplete excision prior to radiotherapy. Radiation doses were either 54 Gy in 30 fractions or 50.4 Gy in 28 fractions (1.8 Gy per fraction). Every patient achieved complete remission (CR) or near-CR. The tumor volume decreased significantly within the first 2 years of follow-up and continued to decrease slowly up to 10 years; no distinct further decrease in tumor volume was observed after 10 years. One patient developed left mandibular hypoplasia 8 years after radiotherapy. Significant volume decrease was achievable within a few years after radiotherapy in benign soft tissue tumors. Therefore, radiotherapy is a viable option for unresectable or incompletely resected benign soft tissue tumors with a minimum risk of complication.

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CiteScore
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