pams人工智能驱动，超声引导腰椎穿刺提高程序准确性：一项试点研究报告。

IF 2.3 Q3 CLINICAL NEUROLOGY

Neurology. Clinical practice Pub Date : 2025-04-01 Epub Date: 2025-02-25 DOI:10.1212/CPJ.0000000000200447

Xuling Lin, Mei Lyn Carissa Lam, Ding Fang Chuang, Joanne Yong Ern Yuen, Liqing Fu, Valerie Jun Zhi Teh, Aynul Marliya, Seyed Ehsan Saffari, Christen Sheng Jie Lim, Yu-Lin Wong, Ying Hao Christopher Seet

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引用次数: 0

摘要

背景：传统的腰椎穿刺（LPs）经常失败，导致诊断延误和风险增加。超声指导提供了更高的成功率，但由于神经轴超声培训和实施挑战，面临采用障碍。超声引导脊柱地标识别针导航系统和位置和角度标记系统（uSINE- pams）旨在解决这些问题：uSINE是用于神经轴向超声引导的机器学习软件；PAMS是一种翻译超声数据的硬件，用于准确的针头插入。最近的发现：一项包含10名患者的初步研究表明，usine - pam引导的LP首次通过成功率为80%，无并发症；患者中位年龄为43岁，中位体重指数为24.5 kg/m2。表明了该系统的可行性。实践意义：该试点研究表明，usine - pam引导的LP是可行的，第一次成功率有望达到80%。一项正在进行的ii期研究（NCT05824546）可能会改变lp的未来实践标准。试验注册信息：该试点研究在ClinicalTrials.gov注册（ID: NCT05824546）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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uSINE-PAMS Artificial Intelligence-Driven, Ultrasound-Guided Lumbar Puncture to Improve Procedural Accuracy: A Pilot Study Report.

Background: Traditional lumbar punctures (LPs) often fail, leading to diagnostic delays and increased risks. Ultrasound guidance provides improved success rates but faces adoption barriers due to neuraxial-ultrasound training and implementation challenges. The Ultrasound-Guided Spinal Landmark Identification With Needle Navigation System and Position and Angular Marking System (uSINE-PAMS) were designed to address these issues: uSINE is a machine-learning software for neuraxial-ultrasound guidance; PAMS is a hardware that translates ultrasound data for accurate needle insertion.

Recent findings: A pilot study with 10 patients showed that uSINE-PAMS-guided LP achieved an 80% first-pass success rate with no complication; the median patient age was 43 years, and the median body mass index was 24.5 kg/m². The uSINE-PAMS system showed feasibility.

Implications for practice: This pilot study showed that uSINE-PAMS-guided LP is feasible with a promising first-pass success rate at 80%. An ongoing phase 2 study (NCT05824546) of uSINE-PAMS may alter future standard of practice for LPs.

Trial registration information: This pilot study is registered under ClinicalTrials.gov (ID: NCT05824546).

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来源期刊

Neurology. Clinical practice CLINICAL NEUROLOGY-

CiteScore

4.00

自引率

0.00%

发文量

期刊介绍： Neurology® Genetics is an online open access journal publishing peer-reviewed reports in the field of neurogenetics. The journal publishes original articles in all areas of neurogenetics including rare and common genetic variations, genotype-phenotype correlations, outlier phenotypes as a result of mutations in known disease genes, and genetic variations with a putative link to diseases. Articles include studies reporting on genetic disease risk, pharmacogenomics, and results of gene-based clinical trials (viral, ASO, etc.). Genetically engineered model systems are not a primary focus of Neurology® Genetics, but studies using model systems for treatment trials, including well-powered studies reporting negative results, are welcome.