肝细胞癌患者肿瘤大小和生存期的相关因素：PLR、PVT 和白蛋白的重要性。

IF 2.5 3区医学 Q3 ONCOLOGY

Oncology Pub Date : 2025-04-08 DOI:10.1159/000545636

Rossella Donghia, Brian Irving Carr, Sezai Yilmaz

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引用次数: 0

摘要

背景与目的：最大肿瘤直径（MTD）是肝细胞癌（HCC）侵袭性的关键特征之一。然而，大体积HCC的临床关联和病因尚不清楚。目的是比较小MTD和大MTD(≤/ bb0 - 6cm) hcc的临床相关性。材料与方法：比较MTD≤/> 6cm hcc的临床特征，并通过logistic回归模型和Cox死亡比例风险模型对临床参数进行分析。结果：hcc越大的患者门静脉血栓形成（PVT）和肿瘤多灶性越高，AST、ALKP和GGT水平越高，白蛋白水平越低。MTD（≤/> 6cm）的logistic回归模型显示PVT和血小板淋巴细胞比(PLR) >150的风险最高，而白蛋白和女性具有保护作用。组合男性，PLR bbb150 + PVT比值比为12.124。在Cox比例风险模型中，死亡风险比最高的是PVT，只有白蛋白具有显著的保护作用。PVT合并低白蛋白的风险比为4.254。结论PVT、白蛋白、PLR和性别在≤/> 6cm MTD中具有重要意义。PVT和白蛋白对生存率有显著影响。

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Factors Relating to Tumor Size and Survival in Patients with Hepatocellular Carcinoma: Significance of Platelet-Lymphocyte Ratio, Portal Vein Thrombosis, and Albumin.

Introduction: Maximum tumor diameter (MTD) is one of the key aggressiveness features of hepatocellular carcinoma (HCC). However, the clinical associations and causes of large size HCC are not well understood. The aim was to compare small and large MTD (≤/>6 cm) HCCs with respect to clinical associations.

Methods: MTD ≤/> 6 cm HCCs were compared by clinical characteristics and analyzed through logistical regression models, as well as Cox proportional hazard models for death, on clinical parameters.

Results: Patients with larger HCCs had more portal vein thrombosis (PVT) and tumor multifocality, higher AST, ALKP and GGT levels and lower albumin levels. A logistic regression model of MTD (≤/>6 cm) showed the highest risk for PVT and platelet-lymphocyte ratio (PLR) >150, while albumin and female gender were protective. The combination of male gender, PLR >150, plus PVT had an odds ratio of 12.124. In Cox proportional hazard models, the highest hazard ratio for death was for PVT, and only albumin was significantly protective. PVT plus low albumin had a hazard ratio of 4.254.

Conclusion: PVT, albumin, PLR, and gender were significant for ≤/>6 cm MTD. PVT and albumin were significant for survival.

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来源期刊

Oncology 医学-肿瘤学

CiteScore

6.00

自引率

2.90%

发文量

审稿时长

6-12 weeks

期刊介绍： Although laboratory and clinical cancer research need to be closely linked, observations at the basic level often remain removed from medical applications. This journal works to accelerate the translation of experimental results into the clinic, and back again into the laboratory for further investigation. The fundamental purpose of this effort is to advance clinically-relevant knowledge of cancer, and improve the outcome of prevention, diagnosis and treatment of malignant disease. The journal publishes significant clinical studies from cancer programs around the world, along with important translational laboratory findings, mini-reviews (invited and submitted) and in-depth discussions of evolving and controversial topics in the oncology arena. A unique feature of the journal is a new section which focuses on rapid peer-review and subsequent publication of short reports of phase 1 and phase 2 clinical cancer trials, with a goal of insuring that high-quality clinical cancer research quickly enters the public domain, regardless of the trial’s ultimate conclusions regarding efficacy or toxicity.