Cog-First:基于片剂的自我认知筛查的标准化。

IF 3.4 3区 医学 Q1 REHABILITATION
Camille Heslot, Alexis Schnitzler, Marion Houot, Valentine Facque, Franck Tarpin-Bernard, Melissa Jeulin, Sarah Besse, Romain Capron, Rajiv Reebye, Emmanuel Mandonnet
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引用次数: 0

摘要

背景:获得性脑损伤可导致细微的认知障碍,尽管影响患者的长期功能预后,但很难发现。Cog-First是一种基于片剂的自我给药认知筛查工具,可在脑损伤急性期约20分钟内评估执行功能、记忆和注意力。目的:本研究的目的是为Cog-First建立可靠的规范数据,以便在患者和参考人群之间进行有意义的比较。设计:横断面研究。环境:本研究在巴黎脑研究所PRISME平台进行。人口:从巴黎大脑研究所的数据库中随机选择了460名说法语的健康志愿者。方法:每个参与者在标准化条件下进行Cog-First评估,包括七个子测试。95名参与者在一个月后进行了替代版本的测试,以评估测试-重测试的效果。通过广义线性模型(GLMs)评估性别、年龄、受教育年限和考试版本的影响及其双向交互作用。从GLMS中提取公式来计算一个修正后的分数,该分数消除了年龄、性别、版本和受教育年限的影响。这使我们能够在健康志愿者人群中得出百分位数,从而允许标准化过程的发展。结果:性别、年龄、受教育程度和版本对多个分项得分有显著影响。基于这些结果,通过在健康志愿者人群中计算校正分数的百分位数来实施标准化过程。重测分析表明,在7个子测试中,有4个子测试有学习效果。结论:Cog-First的标准化导致了根据性别、年龄、教育程度和版本进行调整的评分公式的发展,并集成在软件中进行自动评分。临床康复影响:本研究为Cog-First建立了可靠的规范,实现了有意义的评分解释和临床应用,从而促进了认知障碍的早期发现,并有可能改善患者的预后。该工具在脑损伤患者中的适用性和敏感性有待进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cog-First: standardization of a tablet-based self-administered cognitive screening.

Background: Acquired brain injury can lead to subtle cognitive disorders that can be challenging to detect albeit impacting patients' long-term functional prognosis. Cog-First has been developed as a tablet-based self-administered cognitive screening tool to assess executive function, memory and attention in approximately 20 minutes, in the acute phase following brain injury.

Aim: The aim of this study was to establish reliable normative data for Cog-First to enable meaningful comparisons between patients and a reference population.

Design: Cross-sectional study.

Setting: This study was conducted at the PRISME platform of Paris Brain Institute.

Population: Four hundred and six healthy French-speaking healthy volunteers were randomly selected from the Paris Brain Institute's database.

Methods: Each participant underwent the Cog-First assessment, which comprises seven subtests, in standardized conditions. Ninety-five participants performed the alternative version one month later to assess the test-retest effect. The effects of gender, age, years of education and test version, as well as their two-way interactions, were evaluated by generalized linear models (GLMs). Formulas from the GLMS were extracted to calculate a corrected score that removes the effects of age, sex, version and years of education. This enables us to derive percentiles in a population of healthy volunteers, allowing the development of the standardization process.

Results: The results revealed a significant influence of gender, age, level of education and version on several sub-scores. Based on these results, the standardization process was implemented by calculating the percentiles on the corrected scores in the population of healthy volunteers. Test-retest analyses indicated a learning effect on four out of seven subtests.

Conclusions: The standardization of Cog-First resulted in the development of score formulas adjusted for gender, age, education and version, integrated within the software for automated scoring.

Clinical rehabilitation impact: This study establishes reliable norms for Cog-First, enabling meaningful score interpretation and clinical use, thereby facilitating early detection of cognitive impairments and potentially improving patient outcomes. Further research is necessary to determine the tool's applicability and sensitivity in brain-injured patients.

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来源期刊
CiteScore
8.50
自引率
4.40%
发文量
162
审稿时长
6-12 weeks
期刊介绍: The European Journal of Physical and Rehabilitation Medicine publishes papers of clinical interest in physical and rehabilitation medicine.
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