使用贝达喹啉、德拉马尼和康替唑胺方案治疗1例4个月婴儿广泛耐药前结核病

IF 3.7 3区医学 Q2 INFECTIOUS DISEASES

European Journal of Clinical Microbiology & Infectious Diseases Pub Date : 2025-04-09 DOI:10.1007/s10096-025-05128-2

Wenrui Ding, Lingyun Shen, Ruonan Li, Xiaotao Yang, Yanchun Wang, Yonghan Luo

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引用次数: 0

摘要

耐药性结核病（TB）是全球面临的一项重大挑战，尤其是在诊断和治疗都很困难的儿童中。本报告描述了一名 4 个月大的男婴，他患有前广泛耐药结核病（pre-XDR-TB），并成功接受了贝达喹啉、地拉米尼和contezolid的治疗。患者是一名早产儿，因母亲感染了耐药结核病而患上了严重的肺结核。在因不良反应而中断初始治疗方案后，调整后的治疗方案使结核菌培养转阴，肺部情况明显改善，且无明显不良反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Treatment of pre-extensively drug-resistant tuberculosis in a 4-month-old infant using a regimen of bedaquiline, delamanid, and contezolid.

Drug-resistant tuberculosis (TB) is a significant global challenge, especially in children, where diagnosis and treatment are difficult. This report describes a 4-month-old male infant with pre-extensively drug-resistant tuberculosis (pre-XDR-TB) successfully treated with bedaquiline, delamanid, and contezolid. The patient, born prematurely, developed severe pulmonary TB after exposure to drug-resistant TB from the mother. After discontinuing the initial regimen due to adverse effects, the adjusted regimen resulted in negative TB culture conversion, significant pulmonary improvement, and no notable adverse effects.

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来源期刊

European Journal of Clinical Microbiology & Infectious Diseases 医学-传染病学

CiteScore

10.40

自引率

2.20%

发文量

138

审稿时长

1 months

期刊介绍： EJCMID is an interdisciplinary journal devoted to the publication of communications on infectious diseases of bacterial, viral and parasitic origin.