Radosław Izdebski, Marta Biedrzycka, Paweł Urbanowicz, Dorota Żabicka, Marek Gniadkowski
{"title":"波兰产NDM或vim的Citrobacter spp.， 2011-19：高遗传多样性，ST8， ST18和ST22全球克隆具有更广泛的代表性","authors":"Radosław Izdebski, Marta Biedrzycka, Paweł Urbanowicz, Dorota Żabicka, Marek Gniadkowski","doi":"10.1007/s10096-025-05118-4","DOIUrl":null,"url":null,"abstract":"<p><p>This study focused on genomic epidemiology of metallo-β-lactamase (MBL)-producing Citrobacter spp. in Poland. It included 118 isolates with VIM (n = 100), NDM (n = 17) or IMP (n = 1) enzymes from 2011 to 19, largely C. freundii (n = 94) of 33 sequence types (STs). Three globally-spread STs were more prevalent, namely ST18 (n = 15), ST8 (n = 11) and ST22 (n = 10), each diversified clonally and by VIM and NDM determinants. Only few outbreaks were evidenced, indicating MBL presence to result mainly from independent acquisitions, consistent with co-identifications of Citrobacter isolates (n = 12) with other MBL-producing Enterobacterales. Despite lower outbreak potential, Citrobacter spp. constitute a significant MBL reservoir, requiring attention and surveillance.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"NDM- or VIM-producing Citrobacter spp. in Poland, 2011-19: high genetic diversity with broader representation of ST8, ST18 and ST22 global clones.\",\"authors\":\"Radosław Izdebski, Marta Biedrzycka, Paweł Urbanowicz, Dorota Żabicka, Marek Gniadkowski\",\"doi\":\"10.1007/s10096-025-05118-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This study focused on genomic epidemiology of metallo-β-lactamase (MBL)-producing Citrobacter spp. in Poland. It included 118 isolates with VIM (n = 100), NDM (n = 17) or IMP (n = 1) enzymes from 2011 to 19, largely C. freundii (n = 94) of 33 sequence types (STs). Three globally-spread STs were more prevalent, namely ST18 (n = 15), ST8 (n = 11) and ST22 (n = 10), each diversified clonally and by VIM and NDM determinants. Only few outbreaks were evidenced, indicating MBL presence to result mainly from independent acquisitions, consistent with co-identifications of Citrobacter isolates (n = 12) with other MBL-producing Enterobacterales. Despite lower outbreak potential, Citrobacter spp. constitute a significant MBL reservoir, requiring attention and surveillance.</p>\",\"PeriodicalId\":11782,\"journal\":{\"name\":\"European Journal of Clinical Microbiology & Infectious Diseases\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-04-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Clinical Microbiology & Infectious Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s10096-025-05118-4\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Clinical Microbiology & Infectious Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10096-025-05118-4","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
NDM- or VIM-producing Citrobacter spp. in Poland, 2011-19: high genetic diversity with broader representation of ST8, ST18 and ST22 global clones.
This study focused on genomic epidemiology of metallo-β-lactamase (MBL)-producing Citrobacter spp. in Poland. It included 118 isolates with VIM (n = 100), NDM (n = 17) or IMP (n = 1) enzymes from 2011 to 19, largely C. freundii (n = 94) of 33 sequence types (STs). Three globally-spread STs were more prevalent, namely ST18 (n = 15), ST8 (n = 11) and ST22 (n = 10), each diversified clonally and by VIM and NDM determinants. Only few outbreaks were evidenced, indicating MBL presence to result mainly from independent acquisitions, consistent with co-identifications of Citrobacter isolates (n = 12) with other MBL-producing Enterobacterales. Despite lower outbreak potential, Citrobacter spp. constitute a significant MBL reservoir, requiring attention and surveillance.
期刊介绍：
EJCMID is an interdisciplinary journal devoted to the publication of communications on infectious diseases of bacterial, viral and parasitic origin.
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