血清PINK1作为生化标志物与急性脑出血后神经预后不良、脑卒中相关性肺炎及早期神经功能恶化的前瞻性队列研究

IF 3.2 3区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Clinica Chimica Acta Pub Date : 2025-04-06 DOI:10.1016/j.cca.2025.120282

Weifang Ni, Si-Hua Chen, Le Dai, Yifu Zhou, Chenjun He

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引用次数: 0

摘要

背景：pten诱导的推定激酶1 （PINK1）可能通过维持线粒体功能和完整性来调节神经退行性变。在这里，我们试图确定血清PINK1水平、疾病严重程度、预后不良、早期神经功能恶化（END）和急性脑出血（ICH）后卒中相关性肺炎（SAP）之间的关系。方法：这项前瞻性队列研究共纳入175例脑出血患者和80例对照组。在所有患者入院时和所有对照组入组时测定血清PINK1水平。采用美国国立卫生研究院卒中量表（NIHSS）评分和血肿体积来确定严重程度。SAP、END和ich后6个月不良预后（改良Rankin量表评分：3-6）被记录为三个感兴趣的结局变量。结果：与对照组相比，患者血清PINK1水平显著升高。血清PINK1水平与NIHSS评分、血肿体积和6个月修正Rankin量表评分独立相关。在受限三次样条下，血清PINK1水平与SAP、END和ich后6个月不良预后风险呈线性相关，并与NIHSS评分和血肿体积成为其独立预测因子。受试者工作特征曲线显示，与NIHSS评分和血肿体积相比，血清PINK1水平具有有效的预测能力和相似的识别效率。敏感性分析显示预后相关性强。结论：脑出血后血清PINK1水平显著升高，可准确反映出血强度，有效预测END、SAP及神经预后不良，提示PINK1可能是脑出血患者良好的血清学预后指标。

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A prospective cohort study on serum PINK1 as a biochemical marker in relation to poor neurological prognosis, stroke-associated pneumonia and early neurological deterioration after acute intracerebral hemorrhage

Background

PTEN-induced putative kinase 1 (PINK1) may moderate neurodegeneration via sustaining mitochondrial function and integrity. Here, we attempted to determine relationship between serum PINK1 levels, disease severity, poor prognosis, Early Neurological Deterioration (END) and Stroke-Associated Pneumonia (SAP) following acute Intracerebral Hemorrhage (ICH).

Methods

Altogether, 175 patients with ICH and 80 controls were encompassed in this prospective cohort study. Serum PINK1 levels were measured at admission of all patients and at study entry of all controls. The National Institutes of Health Stroke Scale (NIHSS) scores and hematoma volumes were applied to determine the severity. SAP, END and post-ICH 6-month poor prognosis (modified Rankin Scale scores: 3–6) were recorded as the three outcome variables of interest.

Results

Patients, in contrast to controls, had significantly elevated serum PINK1 levels. Serum PINK1 levels were independently correlated with NIHSS scores, hematoma volumes and 6-month modified Rankin Scale scores. Serum PINK1 levels were linearly correlated with risks of SAP, END and post-ICH 6-month poor prognosis under the restricted cubic spline, as well as along with NIHSS scores and hematoma volumes, became their independent predictors. As demonstrated under receiver operating characteristic curve, serum PINK1 levels displayed effective predictive ability and possessed similar discrimination efficiency, when compared to NIHSS scores and hematoma volumes. Using sensitivity analysis, prognosis association was robust.

Conclusion

Serum PINK1 levels are substantially heightened after ICH, and may accurately mirror hemorrhagic intensity and efficaciously forecast END, SAP, and poor neurological prognosis, signifying that PINK1 may be a serological prognosticator of good prospect in ICH.

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来源期刊

Clinica Chimica Acta 医学-医学实验技术

CiteScore

10.10

自引率

2.00%

发文量

1268

审稿时长

23 days

期刊介绍： The Official Journal of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Clinica Chimica Acta is a high-quality journal which publishes original Research Communications in the field of clinical chemistry and laboratory medicine, defined as the diagnostic application of chemistry, biochemistry, immunochemistry, biochemical aspects of hematology, toxicology, and molecular biology to the study of human disease in body fluids and cells. The objective of the journal is to publish novel information leading to a better understanding of biological mechanisms of human diseases, their prevention, diagnosis, and patient management. Reports of an applied clinical character are also welcome. Papers concerned with normal metabolic processes or with constituents of normal cells or body fluids, such as reports of experimental or clinical studies in animals, are only considered when they are clearly and directly relevant to human disease. Evaluation of commercial products have a low priority for publication, unless they are novel or represent a technological breakthrough. Studies dealing with effects of drugs and natural products and studies dealing with the redox status in various diseases are not within the journal''s scope. Development and evaluation of novel analytical methodologies where applicable to diagnostic clinical chemistry and laboratory medicine, including point-of-care testing, and topics on laboratory management and informatics will also be considered. Studies focused on emerging diagnostic technologies and (big) data analysis procedures including digitalization, mobile Health, and artificial Intelligence applied to Laboratory Medicine are also of interest.