氧化还原-中性光催化脱羧自由基加成/酰基迁移级联过程：模块化获得功能化α-（杂）芳基-α-氨基酮。

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-03-24 DOI:10.1039/d5ob00290g

Haibo Huang , Yu Zhao , Li Zhang , Yan Li , Yewen Fang

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引用次数: 0

摘要

本文以还原自由基-极性交叉为关键过程，成功地建立了一个稳健实用的N→C酰基迁移反应方案。在氧化还原-中性光催化作用下，多种酰胺类化合物可与羧酸反应生成α-（杂）芳基-α-氨基酮。这种脱羧自由基加成/酰基迁移级联过程具有底物范围广、功能相容性好、反应条件温和等特点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Redox-neutral-photocatalyzed decarboxylative radical addition/acyl migration cascade process: modular access to functionalized α-(hetero)aryl-α-aminoketones†

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Redox-neutral-photocatalyzed decarboxylative radical addition/acyl migration cascade process: modular access to functionalized α-(hetero)aryl-α-aminoketones†

Herein, using reductive radical-polar crossover as a key process, a robust and practical protocol for the N → C acyl migration reaction has been successfully developed. A variety of enamides could react with carboxylic acids for modular access to α-(hetero)aryl-α-aminoketones enabled by redox-neutral photocatalysis. This decarboxylative radical addition/acyl migration cascade process features a broad substrate scope, good functional compatibility, and mild reaction conditions.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.