凝固芽孢杆菌198和l -谷氨酰胺通过调节肠道微生物群落结构和多样性，在5- fu诱导的BALB/c小鼠模型中联合减轻肠道黏膜炎。

IF 2.6 3区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Food and Drug Analysis Pub Date : 2025-03-31 DOI:10.38212/2224-6614.3535

Wei-Jen Chen, Siou-Ru Shen, Wei-Hsuan Hsu, Bao-Hong Lee, Yu-Shan Wei, Hui-Fang Chu, Ming-Chung Tseng, Tang-Long Shen

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引用次数: 0

摘要

5-氟尿嘧啶（5-FU）破坏肠道细胞，导致肠道微生物群生态失调。本研究探讨了凝结芽孢杆菌-198 （BC198）缓解5-氟尿嘧啶引起的肠道菌群失衡和粘膜炎的潜力。l -谷氨酰胺被用于缓解粘膜炎，本研究发现BC198对肠道具有保护作用，包括维持健康的微生物群和减少肠道炎症，无论是否联合使用l -谷氨酰胺。因此，它可以帮助减少5-氟尿嘧啶引起的肠道环境恶化。BC198可以提供给癌症患者，防止严重的副作用，从而改善其治疗效果和营养状况。

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Bacillus coagulans 198 and L-glutamine in combination attenuated intestinal mucositis in a 5-FU-induced BALB/c mouse model via modulation of gut microbial community structure and diversity.

5-Fluorouracil (5-FU) disrupts intestinal cells and causes dysbiosis in the gut microbiota. This study explores the potential of Bacillus coagulans-198 (BC198) to mitigate gut microbiota imbalance and mucositis caused by 5-fluorouracil. L-glutamine is used to alleviate mucositis, and this study found that BC198 exhibits protective effects on the gut, including maintaining a healthy microbiota and reducing intestinal inflammation, regardless of whether L-glutamine is used in combination. Therefore, it can help reduce the deterioration of the gut environment caused by 5-fluorouracil. BC198 can be provided to cancer patients to prevent severe side effects, thereby improving their treatment outcomes and nutritional status.

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来源期刊

Journal of Food and Drug Analysis 医学-食品科技

CiteScore

6.30

自引率

2.80%

发文量

审稿时长

3.8 months

期刊介绍： The journal aims to provide an international platform for scientists, researchers and academicians to promote, share and discuss new findings, current issues, and developments in the different areas of food and drug analysis. The scope of the Journal includes analytical methodologies and biological activities in relation to food, drugs, cosmetics and traditional Chinese medicine, as well as related disciplines of topical interest to public health professionals.