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引用次数: 0
摘要
明确他汀类药物的使用与痴呆风险的关系,进一步指导他汀类药物的临床应用。本文利用计算机检索Pubmed、Medline、Cochrane、Embase、Web of Science、Weipu、CBM、万方、CNKI等中外文数据库,纳入建库至2020年12月期间符合标准的文献,使用Revman 5.1软件和Stata15.0软件进行meta分析。在纳入的34项观察性研究中,根据临床试验类型、参与者性别、载脂蛋白E-4 (ApoEε4)等位基因的存在与否和使用时间进行分层亚组分析。结论表明:(1)使用他汀类药物可显著降低痴呆风险;(2)降低痴呆风险的性别差异不显著;(3)与服用他汀类药物的时间相比,连续使用他汀类药物≥1年可显著降低痴呆风险
Statins and the risk of dementia: a meta-analysis.
Clarify the relationship between the use of statins and the risk of dementia, and further guide the clinical application of statins. This paper uses computer search Chinese and foreign language databases Pubmed, Medline, Cochrane, Embase, Web of Science, Weipu, CBM, Wanfang, CNKI, etc., to include the literature that meets the standards from the establishment of the library to December 2020, and uses Revman 5.1 software and Stata15.0 software for meta-analysis. Of the 34 included observational studies, stratified subgroup analyses were performed based on the type of clinical trial, sex of participants, presence or absence of apolipoprotein E-4 (ApoEε4) allele, and duration of use. The conclusions showed that (1) the use of statins can significantly reduce the risk of dementia; (2) There is no significant sex difference in reducing the risk of dementia; (3) Continuous use of statins for ≥ 1 year can significantly reduce the risk of dementia compared with the time of taking the drug for < 1 year; (4) Compared with subjects with negative ApoEε4 allele, the use of statins has a more significant effect on reducing the risk of dementia in subjects carrying the ApoEε4 allele.
期刊介绍:
Peer-reviewed and published quarterly, Acta Neurologica Belgicapresents original articles in the clinical and basic neurosciences, and also reports the proceedings and the abstracts of the scientific meetings of the different partner societies. The contents include commentaries, editorials, review articles, case reports, neuro-images of interest, book reviews and letters to the editor.
Acta Neurologica Belgica is the official journal of the following national societies:
Belgian Neurological Society
Belgian Society for Neuroscience
Belgian Society of Clinical Neurophysiology
Belgian Pediatric Neurology Society
Belgian Study Group of Multiple Sclerosis
Belgian Stroke Council
Belgian Headache Society
Belgian Study Group of Neuropathology