新型吡唑[1,5-a]嘧啶-3,5-二胺作为nSMase2抑制剂

IF 4 3区医学 Q2 CHEMISTRY, MEDICINAL

ACS Medicinal Chemistry Letters Pub Date : 2025-03-27 DOI:10.1021/acsmedchemlett.5c0013410.1021/acsmedchemlett.5c00134

Jian Rong, and , Steven H. Liang*,

引用次数: 0

摘要

本专利强调新型吡唑[1,5-a]嘧啶-3,5-二胺作为中性鞘磷脂酶2 （nSMase2）抑制剂。它提供了吡唑[1,5-a]嘧啶-3,5-二胺化合物的详细信息，它们的药物组成，用途和潜在的治疗应用于nsmase2相关疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Novel Pyrazolo[1,5-a]pyrimidine-3,5-diamines as nSMase2 Inhibitors

This patent highlights novel pyrazolo[1,5-a]pyrimidine-3,5-diamines as neutral sphingomyelinase 2 (nSMase2) inhibitors. It provides detailed information on pyrazolo[1,5-a]pyrimidine-3,5-diamine compounds, their pharmaceutical composition, use, and potential therapeutic applications for nSMase2-related diseases.

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来源期刊

ACS Medicinal Chemistry Letters CHEMISTRY, MEDICINAL-

CiteScore

7.30

自引率

2.40%

发文量

328

审稿时长

1 months

期刊介绍： ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to: Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics) Biological characterization of new molecular entities in the context of drug discovery Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc. Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic Mechanistic drug metabolism and regulation of metabolic enzyme gene expression Chemistry patents relevant to the medicinal chemistry field.