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IF 4.2 3区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of Materials Science: Materials in Medicine Pub Date : 2025-04-09 DOI:10.1007/s10856-025-06877-4

Sreejita Dhar, Faraz Ahmad, Aditi Deshpande, Sandeep Singh Rana, Toufeeq Ahmed A, Swagatika Priyadarsini

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引用次数: 0

摘要

三维打印（3DP）的快速发展对医疗领域产生了重大影响。以神经学为例，3DP 在个性化手术规划和教育方面发挥了关键作用。此外，它还促进了植入物、微流体设备和光遗传探针的制造，为医疗和研究应用带来了重大影响。此外，3D 打印鼻腔铸模在定向脑部给药方面也大有可为。3DP 还有助于创建三维 "模型"，以配合神经成像技术的发展，并设计复杂的物体来研究感官神经生物学。此外，三维生物打印（3DBP）是三维打印与细胞生物学的融合，它的出现为神经组织工程开辟了新的途径。以有效和合乎道德的方式创建类似组织的生物仿生结构，可以进行机理、再生和治疗评估。虽然个别综述探讨了 3DP 或 3DBP 的应用，但一直缺乏一份全面的综述，涵盖这两种技术在神经外科、神经成像和神经再生等多个方面的成功案例。本综述旨在整合 3DP 和 3DBP 在各个神经科学领域的最新成果，鼓励神经学家、神经生物学家和工程师开展跨学科研究，以促进 3DP 和 3DBP 方法在神经科学研究和实践的新领域中的进一步探索。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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3-Dimensional printing and bioprinting in neurological sciences: applications in surgery, imaging, tissue engineering, and pharmacology and therapeutics

The rapid evolution of three-dimensional printing (3DP) has significantly impacted the medical field. In neurology for instance, 3DP has been pivotal in personalized surgical planning and education. Additionally, it has facilitated the creation of implants, microfluidic devices, and optogenetic probes, offering substantial implications for medical and research applications. Additionally, 3D printed nasal casts are showing great promise for targeted brain drug delivery. 3DP has also aided in creating 3D “phantoms” aligning with advancements in neuroimaging, and in the design of intricate objects for investigating the neurobiology of sensory perception. Furthermore, the emergence of 3D bioprinting (3DBP), a fusion of 3D printing and cell biology, has created new avenues in neural tissue engineering. Effective and ethical creation of tissue-like biomimetic constructs has enabled mechanistic, regenerative, and therapeutic evaluations. While individual reviews have explored the applications of 3DP or 3DBP, a comprehensive review encompassing the success stories across multiple facets of both technologies in neurosurgery, neuroimaging, and neuro-regeneration has been lacking. This review aims to consolidate recent achievements of both 3DP and 3DBP across various neurological science domains to encourage interdisciplinary research among neurologists, neurobiologists, and engineers, in order to promote further exploration of 3DP and 3DBP methodologies to novel areas of neurological science research and practice.

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来源期刊

Journal of Materials Science: Materials in Medicine 工程技术-材料科学：生物材料

CiteScore

8.00

自引率

0.00%

发文量

审稿时长

3.5 months

期刊介绍： The Journal of Materials Science: Materials in Medicine publishes refereed papers providing significant progress in the application of biomaterials and tissue engineering constructs as medical or dental implants, prostheses and devices. Coverage spans a wide range of topics from basic science to clinical applications, around the theme of materials in medicine and dentistry. The central element is the development of synthetic and natural materials used in orthopaedic, maxillofacial, cardiovascular, neurological, ophthalmic and dental applications. Special biomedical topics include biomaterial synthesis and characterisation, biocompatibility studies, nanomedicine, tissue engineering constructs and cell substrates, regenerative medicine, computer modelling and other advanced experimental methodologies.