Malihe Pooresmaeil, Rahim Safarpour, Hassan Namazi
{"title":"淀粉生物聚合物修饰双金属金属-有机框架（Mn-Zn）生物纳米复合材料的制备及其ph控制给药性能","authors":"Malihe Pooresmaeil, Rahim Safarpour, Hassan Namazi","doi":"10.1007/s10924-025-03545-0","DOIUrl":null,"url":null,"abstract":"<div><p>For the first time, this research aims to prepare a new photoluminescence and porous bio-nanocomposite of the starch nanoparticles@metal-organic framework (Manganese-Zinc) (PSt NPs@MOF(Mn-Zn)) through the composition of starch nanoparticles (St NPs), carbon dots (CDs), and MOF(Mn-Zn) in three steps. The findings of performed characterization techniques approved the success in the fabrication of the PSt NPs@MOF(Mn-Zn). In the following, the potential of PSt NPs@MOF(Mn-Zn) was evaluated as a drug carrier for co-delivery of doxorubicin (DOX) and 5-fluorouracil (5-Fu) and ((5-Fu+DOX)@PSt NPs@MOF(Mn-Zn)) was obtained. Brunauer-Emmett-Teller (BET) test showed that the surface area and total pore volume of 275.98 m<sup>2</sup> g<sup>-1</sup> and 0.4885 cm<sup>3</sup> g<sup>-1</sup> for PSt NPs@MOF(Mn-Zn) were reduced to 3.8535 m<sup>2</sup> g<sup>-1</sup> and 0.0029023 cm<sup>3</sup> g<sup>-1</sup> for (5-Fu+DOX)@PSt NPs@MOF(Mn-Zn) that is a good indication of the loading of studied drug molecules in the prepared system. Moreover, the higher release rate of DOX and 5-Fu at pH 5.0 than pH 7.4 is one of the main signs of the system's suitability in cancer treatment. The observation of HeLa cell viability up to 70% after treatment with PSt NPs@MOF(Mn-Zn) approved its biocompatibility and its potential for use as a drug carrier. Overall it can be concluded that the PSt NPs@MOF(Mn-Zn) has the criteria to be proposed as a new bio-nanocomposite for controlled DOX and 5-Fu delivery.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 5","pages":"2385 - 2401"},"PeriodicalIF":4.7000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Preparation of Starch Biopolymer Decorated Bimetallic Metal-Organic Framework (Mn-Zn) Bio-nanocomposite for pH-Controlled Drug Delivery\",\"authors\":\"Malihe Pooresmaeil, Rahim Safarpour, Hassan Namazi\",\"doi\":\"10.1007/s10924-025-03545-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>For the first time, this research aims to prepare a new photoluminescence and porous bio-nanocomposite of the starch nanoparticles@metal-organic framework (Manganese-Zinc) (PSt NPs@MOF(Mn-Zn)) through the composition of starch nanoparticles (St NPs), carbon dots (CDs), and MOF(Mn-Zn) in three steps. The findings of performed characterization techniques approved the success in the fabrication of the PSt NPs@MOF(Mn-Zn). In the following, the potential of PSt NPs@MOF(Mn-Zn) was evaluated as a drug carrier for co-delivery of doxorubicin (DOX) and 5-fluorouracil (5-Fu) and ((5-Fu+DOX)@PSt NPs@MOF(Mn-Zn)) was obtained. Brunauer-Emmett-Teller (BET) test showed that the surface area and total pore volume of 275.98 m<sup>2</sup> g<sup>-1</sup> and 0.4885 cm<sup>3</sup> g<sup>-1</sup> for PSt NPs@MOF(Mn-Zn) were reduced to 3.8535 m<sup>2</sup> g<sup>-1</sup> and 0.0029023 cm<sup>3</sup> g<sup>-1</sup> for (5-Fu+DOX)@PSt NPs@MOF(Mn-Zn) that is a good indication of the loading of studied drug molecules in the prepared system. Moreover, the higher release rate of DOX and 5-Fu at pH 5.0 than pH 7.4 is one of the main signs of the system's suitability in cancer treatment. The observation of HeLa cell viability up to 70% after treatment with PSt NPs@MOF(Mn-Zn) approved its biocompatibility and its potential for use as a drug carrier. Overall it can be concluded that the PSt NPs@MOF(Mn-Zn) has the criteria to be proposed as a new bio-nanocomposite for controlled DOX and 5-Fu delivery.</p></div>\",\"PeriodicalId\":659,\"journal\":{\"name\":\"Journal of Polymers and the Environment\",\"volume\":\"33 5\",\"pages\":\"2385 - 2401\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2025-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Polymers and the Environment\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10924-025-03545-0\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENGINEERING, ENVIRONMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Polymers and the Environment","FirstCategoryId":"5","ListUrlMain":"https://link.springer.com/article/10.1007/s10924-025-03545-0","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, ENVIRONMENTAL","Score":null,"Total":0}
Preparation of Starch Biopolymer Decorated Bimetallic Metal-Organic Framework (Mn-Zn) Bio-nanocomposite for pH-Controlled Drug Delivery
For the first time, this research aims to prepare a new photoluminescence and porous bio-nanocomposite of the starch nanoparticles@metal-organic framework (Manganese-Zinc) (PSt NPs@MOF(Mn-Zn)) through the composition of starch nanoparticles (St NPs), carbon dots (CDs), and MOF(Mn-Zn) in three steps. The findings of performed characterization techniques approved the success in the fabrication of the PSt NPs@MOF(Mn-Zn). In the following, the potential of PSt NPs@MOF(Mn-Zn) was evaluated as a drug carrier for co-delivery of doxorubicin (DOX) and 5-fluorouracil (5-Fu) and ((5-Fu+DOX)@PSt NPs@MOF(Mn-Zn)) was obtained. Brunauer-Emmett-Teller (BET) test showed that the surface area and total pore volume of 275.98 m2 g-1 and 0.4885 cm3 g-1 for PSt NPs@MOF(Mn-Zn) were reduced to 3.8535 m2 g-1 and 0.0029023 cm3 g-1 for (5-Fu+DOX)@PSt NPs@MOF(Mn-Zn) that is a good indication of the loading of studied drug molecules in the prepared system. Moreover, the higher release rate of DOX and 5-Fu at pH 5.0 than pH 7.4 is one of the main signs of the system's suitability in cancer treatment. The observation of HeLa cell viability up to 70% after treatment with PSt NPs@MOF(Mn-Zn) approved its biocompatibility and its potential for use as a drug carrier. Overall it can be concluded that the PSt NPs@MOF(Mn-Zn) has the criteria to be proposed as a new bio-nanocomposite for controlled DOX and 5-Fu delivery.
期刊介绍：
The Journal of Polymers and the Environment fills the need for an international forum in this diverse and rapidly expanding field. The journal serves a crucial role for the publication of information from a wide range of disciplines and is a central outlet for the publication of high-quality peer-reviewed original papers, review articles and short communications. The journal is intentionally interdisciplinary in regard to contributions and covers the following subjects - polymers, environmentally degradable polymers, and degradation pathways: biological, photochemical, oxidative and hydrolytic; new environmental materials: derived by chemical and biosynthetic routes; environmental blends and composites; developments in processing and reactive processing of environmental polymers; characterization of environmental materials: mechanical, physical, thermal, rheological, morphological, and others; recyclable polymers and plastics recycling environmental testing: in-laboratory simulations, outdoor exposures, and standardization of methodologies; environmental fate: end products and intermediates of biodegradation; microbiology and enzymology of polymer biodegradation; solid-waste management and public legislation specific to environmental polymers; and other related topics.
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