基于氧化石墨烯金纳米复合材料的SERS传感器用于营养补充剂中锌复合物的检测

IF 3.8 3区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

Optical Materials Pub Date : 2025-04-05 DOI:10.1016/j.optmat.2025.117024

Vennila Preethi S , Gowri Annasamy

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引用次数: 0

摘要

微量营养素是调节新陈代谢和生物物理、生化过程的关键因素，必须通过饮食或补充获得。在多种微量营养素中，锌在调节细胞生长、代谢、免疫反应和伤口愈合等方面起着至关重要的作用。用于检测营养补充剂中锌配合物的常规诊断分析涉及复杂的仪器和费力的样品处理程序。在这项研究中，展示了一种利用表面增强拉曼光谱（SERS）检测营养补充剂中锌复合物的无标签传感技术。本文提出了一种利用氧化石墨烯金纳米复合材料（GOAu）的协同效应来增强锌配合物固有的弱拉曼特征峰的技术，并观察到与单独的氧化石墨烯和金纳米颗粒相比，增强了约21倍。制备了一种简单的GOAu滴铸刚性衬底，并利用其固有特征峰在265、690、952和1452 cm−1处检测营养补充剂中的锌络合物。此外，利用COMSOL Multiphysics 5.5模拟了纳米复合材料协同增强的理论研究。本文研究了不同浓度醋酸锌散射光场强度随折射率（RI）变化的变化规律。此外，对纳米复合材料进行了优化，其中直径为60 nm的纳米金纳米复合材料具有更好的拉曼信号强度。该SERS衬底的检测限为1 nM，增强因子为2.1 × 107。此外，该传感器可作为营养补充剂中微量锌复合物检测的筛选工具。

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Graphene oxide gold nanocomposites based SERS sensor for detection of Zinc complex in nutritional supplements

Micronutrients, a key factor essential for regulating metabolism and biophysical, biochemical processes, must be obtained through diet or supplementation. Among the various micronutrients, zinc plays a vital role in regulating cell growth, metabolism, immune response, and wound healing. The conventional diagnostic assay for detecting zinc complexes in nutritional supplements involves sophisticated instruments and laborious sample processing procedures. In this study, a label free sensing technique is demonstrated for the detection of zinc complex in nutritional supplements utilizing Surface Enhanced Raman Spectroscopy (SERS). Herein, a technique to enhance the inherent weak Raman characteristic peaks of zinc complex is proposed by utilizing the synergistic effect of graphene oxide gold nanocomposites (GOAu) and observed ∼21-fold enhancement as compared to individual graphene oxide and gold nanoparticles. A simple GOAu drop cast rigid substrate was fabricated and explored for detection of zinc complex in nutritional supplements with the inherent characteristic peaks at 265, 690, 952, and 1452 cm⁻¹. In addition, the theoretical investigation of synergistic enhancement of nanocomposites is simulated using COMSOL Multiphysics 5.5. Herein, the change in the scattered light field intensity for various concentrations of zinc acetate due to the change of refractive index (RI) was investigated. Additionally, optimization of nanocomposites was performed in which GOAu nanocomposites with gold nanoparticle diameter of 60 nm yielded better Raman signal intensity. The proposed SERS substrate achieved a detection limit of 1 nM with an enhancement factor of 2.1 × 10⁷. Further, this sensor could be a screening tool for the trace-level detection of zinc complexes in nutritional supplements.

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来源期刊

Optical Materials 工程技术-材料科学：综合

CiteScore

6.60

自引率

12.80%

发文量

1265

审稿时长

38 days

期刊介绍： Optical Materials has an open access mirror journal Optical Materials: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. The purpose of Optical Materials is to provide a means of communication and technology transfer between researchers who are interested in materials for potential device applications. The journal publishes original papers and review articles on the design, synthesis, characterisation and applications of optical materials. OPTICAL MATERIALS focuses on: • Optical Properties of Material Systems; • The Materials Aspects of Optical Phenomena; • The Materials Aspects of Devices and Applications. Authors can submit separate research elements describing their data to Data in Brief and methods to Methods X.