在巴西南部的三级保健医院铜绿假单胞菌的白粉病发病率增加

IF 3 4区医学 Q2 INFECTIOUS DISEASES

Brazilian Journal of Infectious Diseases Pub Date : 2025-04-10 DOI:10.1016/j.bjid.2025.104523

Patricia Orlandi Barth , Dariane Castro Pereira , Camila Mörschbächer Wilhelm , Kellen Figueira Tragnago , Afonso Luís Barth

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引用次数: 0

摘要

耐碳青霉烯铜绿假单胞菌（CRPA）是世界卫生组织认定的重点防治病原菌之一。随着CRPA碳青霉烯酶生产商在全球范围内的增加，本研究的目的是评估巴西一家三级保健医院CRPA中碳青霉烯酶的流行情况。采用多重实时聚合酶链反应（qPCR-HRM）对2021年9月至2024年5月期间鉴定的395个CRPA进行碳青霉烯酶基因：blaKPC、blaNDM、blaOXA-48-like、blaIMP、blaVIM、blaSPM和blaGES的评估。在第一个分析时期（2021年9月至12月），近70%的分离株对7个检测基因呈阴性，其中27.3%的CRPA中发现了blaNDM。在接下来的学期中，blaNDM的增长如下：2022年1月至6月= 29.8%；2022年7月至12月= 43.8%；2023年1月至6月= 42.4%；2023年7月至12月= 58.9%，2024年1月至5月= 59.5%。其他碳青霉烯酶的流行率仍然很低。这些结果表明blaNDM基因的重要增加，克服了我们机构的CRPA非碳青霉烯酶生产者。

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Increased rates of blaNDM in Pseudomonas aeruginosa in a tertiary care hospital in southern Brazil

Carbapenem-Resistant Pseudomonas Aeruginosa (CRPA) is considered as one of the high priority pathogens by the World Health Organization. As CRPA carbapenemase producers have increased worldwide, the aim of this study was to evaluate the carbapenemase prevalence in CRPA at a tertiary care hospital in Brazil”. All 395 CRPA identified in the period of September 2021 to May 2024 were evaluated by multiplex real-time polymerase chain reaction (qPCR-HRM) for the following carbapenemase genes: bla_KPC, bla_NDM, bla_OXA-48-like, bla_IMP, bla_VIM, bla_SPM and bla_GES. In the first period analyzed (September to December 2021), almost 70 % of the isolates were negative for the 7 tested genes, and the bla_NDM was found in 27.3 % of the CRPA. In the following semesters there was an increase of bla_NDM as follows: January to June of 2022 = 29.8 %; July to December of 2022 = 43.8 %; January to June of 2023 = 42.4 %; July to December 2023 = 58.9 % and January to May of 2024 = 59.5 % of bla_NDM. The prevalence of the other carbapenemases remained low. These results indicated an important increase of the bla_NDM gene, overcoming the CRPA non-carbapenemase producers in our institution.

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来源期刊

Brazilian Journal of Infectious Diseases 医学-传染病学

CiteScore

5.50

自引率

0.00%

发文量

925

审稿时长

41 days

期刊介绍： The Brazilian Journal of Infectious Diseases is the official publication of the Brazilian Society of Infectious Diseases (SBI). It aims to publish relevant articles in the broadest sense on all aspects of microbiology, infectious diseases and immune response to infectious agents. The BJID is a bimonthly publication and one of the most influential journals in its field in Brazil and Latin America with a high impact factor, since its inception it has garnered a growing share of the publishing market.