预防性塞来昔布或曲马多/对乙酰氨基酚加入下颌阻生第三磨牙拔除术后标准疼痛管理的镇痛效果：一项多中心、随机、双盲、安慰剂对照试验

IF 4.1 4区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Evidence-Based Dental Practice Pub Date : 2025-03-11 DOI:10.1016/j.jebdp.2025.102135

SOO-HO KIM , SOMI KIM , YOON-SEON KIM , MI-KYOUNG SONG , JI-YEON KANG

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引用次数: 0

摘要

目的：本研究旨在评估在下颌阻生第三磨牙拔除术后标准镇痛中加入单剂量塞来昔布200mg （Cc）或曲马多37.5 mg/对乙酰氨基酚325.0 mg （T/A）的有效性和安全性。方法在这项多中心、前瞻性、随机、双盲、安慰剂对照、受试者交叉的研究中，参与者被随机分为2组(A组为Cc或安慰剂；B组为T/A或安慰剂)，每隔1个月行双侧阻生下颌第三磨牙拔牙。在基线特征的基础上，评估视觉模拟量表（VAS）疼痛强度、首次感知疼痛发生、抢救用药和不良事件。结果每组共33名受试者完成试验。Cc减轻疼痛3(−0.91±2.17；P = .011)和6小时(−0.85±2.24；P = .018)，而T/A减轻疼痛为1(−1.40±2.37；P & lt;.001), 2(−0.79±2.32；P = .030)，6小时(−0.91±1.94；P = .006)，其他时间有一些不显著的降低。Cc和T/A均能有效减轻初觉疼痛。Cc显著降低疼痛强度，T/A显著延迟疼痛感觉。两种药物对抢救用药需求和不良事件发生率均无显著影响。结论基于这些结果，Cc和T/A似乎都有助于减少下颌阻生第三磨牙拔牙后的术后疼痛，且没有明显的不良反应。

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查看原文本刊更多论文

ANALGESIC EFFECTS OF PREEMPTIVE CELECOXIB OR TRAMADOL/ACETAMINOPHEN ADDED TO STANDARD POSTOPERATIVE PAIN MANAGEMENT IN IMPACTED MANDIBULAR THIRD MOLAR EXTRACTION: A MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL

Objectives

This study aimed to assess the efficacy and safety of adding single-dose preemptive celecoxib 200 mg (Cc) or tramadol 37.5 mg/acetaminophen 325.0 mg (T/A) to standard postoperative analgesia after impacted mandibular third molar extraction, a design not previously explored.

Methods

In this multicenter, prospective, randomized, double-blind, placebo-controlled, crossover within-subject study, participants were randomly assigned to 2 groups (Cc or placebo for group A; T/A or placebo for group B) and underwent impacted mandibular third molar extraction on both sides at 1-month intervals. Along with baseline characteristics, pain intensity in Visual Analogue Scale (VAS), first perceived pain occurrence, rescue medication use, and adverse events were evaluated.

Results

A total of 33 participants per group completed the trial. Cc reduced pain at 3 (−0.91 ± 2.17; P = .011) and 6 hours (−0.85 ± 2.24; P = .018), while T/A reduced pain at 1 (−1.40 ± 2.37; P < .001), 2 (−0.79 ± 2.32; P = .030), and 6 hours (−0.91 ± 1.94; P = .006) postextraction, with some insignificant reductions at other times. Both Cc and T/A were effective in reducing the first perceived pain. Notably, Cc significantly decreased pain intensity, T/A significantly delayed the pain perception. Both drugs had no significant effect on the need for rescue medication or adverse event rates.

Conclusions

Based on these results, both Cc and T/A appears to aid in reducing postoperative pain following impacted mandibular third molar extraction without significant adverse effects.

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来源期刊

Journal of Evidence-Based Dental Practice DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

6.00

自引率

16.70%

发文量

105

审稿时长

28 days

期刊介绍： The Journal of Evidence-Based Dental Practice presents timely original articles, as well as reviews of articles on the results and outcomes of clinical procedures and treatment. The Journal advocates the use or rejection of a procedure based on solid, clinical evidence found in literature. The Journal''s dynamic operating principles are explicitness in process and objectives, publication of the highest-quality reviews and original articles, and an emphasis on objectivity.