生物医学钛植入物上双层包覆氧化铈纳米粒子和钬取代羟基磷灰石/聚丙烯酸复合材料的环保合成

IF 4.4 3区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Inorganic Chemistry Communications Pub Date : 2025-04-09 DOI:10.1016/j.inoche.2025.114480

Ponnusamy Saravanakumar , Raji Ramachandran , Ratna Surya Alwi , Dhanaraj Gopi

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引用次数: 0

摘要

本研究提出了一种生态友好的方法，利用电泳沉积在钛（Ti）植入物上合成双层涂层氧化铈纳米颗粒（CeO2NPs）和钬取代羟基磷灰石/聚丙烯酸（CeO2NPs/nHo-HAp/PAA）生物复合材料。利用生物废物衍生的前体，该方法为制造多功能植入物涂层提供了一种可持续的选择。XRD的结构分析证实了CeO2/nHo在HAp中的成功掺入，而HRSEM则显示了一种有利于骨整合的均匀多孔涂层。该生物复合材料具有优异的机械强度（360 Hv），在模拟体液中的耐腐蚀性提高，对大肠杆菌和金黄色葡萄球菌具有很强的抗菌作用。值得注意的是，细胞毒性研究显示，对骨肉瘤细胞（IC50 = 35.27 µg/mL）具有有效的抗癌活性，对健康的Vero细胞（IC50 = 421.1 µg/mL）具有最小的毒性。溶胀和降解研究证实了良好的生物活性和长期稳定性。这些发现突出了CeO2NPs/nHo-HAp/PAA作为一种可持续和多功能的骨科植入物涂层的潜力，增强了机械完整性、抗菌性和抗癌性能，为未来的生物医学应用铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Eco-friendly synthesis of dual-layer coated cerium oxide nanoparticles and holmium-substituted hydroxyapatite/polyacrylic acid composite on titanium implants for biomedical applications

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Eco-friendly synthesis of dual-layer coated cerium oxide nanoparticles and holmium-substituted hydroxyapatite/polyacrylic acid composite on titanium implants for biomedical applications

This study presents an eco-friendly approach to synthesizing a dual-layer coated cerium oxide nanoparticles (CeO₂NPs) and holmium-substituted hydroxyapatite/polyacrylic acid (CeO₂NPs/nHo-HAp/PAA) biocomposite on titanium (Ti) implants for orthopedic applications using electrophoretic deposition. Utilizing biogenic waste-derived precursors, this method offers a sustainable alternative for fabricating multifunctional implant coatings. Structural analysis via XRD confirmed successful CeO₂/nHo incorporation into HAp, while HRSEM revealed a uniform, porous coating beneficial for bone integration. The biocomposite demonstrated superior mechanical strength (360 Hv), improved corrosion resistance in simulated body fluid, and strong antibacterial efficacy against E. coli and S. aureus. Notably, cytotoxicity studies showed potent anticancer activity against osteosarcoma cells (IC₅₀ = 35.27 µg/mL) with minimal toxicity to healthy Vero cells (IC₅₀ = 421.1 µg/mL). Swelling and degradation studies confirmed favourable bioactivity and long term stability. These findings highlight the potential of CeO₂NPs/nHo-HAp/PAA as a sustainable and multifunctional coating for orthopedic implants, enhancing mechanical integrity, antibacterial resistance, and anticancer properties, paving the way for future biomedical applications.

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来源期刊

Inorganic Chemistry Communications 化学-无机化学与核化学

CiteScore

5.50

自引率

7.90%

发文量

1013

审稿时长

53 days

期刊介绍： Launched in January 1998, Inorganic Chemistry Communications is an international journal dedicated to the rapid publication of short communications in the major areas of inorganic, organometallic and supramolecular chemistry. Topics include synthetic and reaction chemistry, kinetics and mechanisms of reactions, bioinorganic chemistry, photochemistry and the use of metal and organometallic compounds in stoichiometric and catalytic synthesis or organic compounds.