咪唑酮片段间含聚亚甲基连接的双二吡罗-吲哚啉-吡咯烷-咪唑酮类化合物

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-04-05 DOI:10.1016/j.tetlet.2025.155589

V.S. Polyakov, E.V. Pervakova, Yu.K. Grishin, E.K. Beloglazkina

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引用次数: 0

摘要

提出了在咪唑酮环的N(3)个氮原子之间用C4、C6和C8烷基连接螺环片段的合成双（二吡罗-咪唑酮-吡咯烷-吲哚酮）方法。采用α，ω-二烷基胺与异硫氰酸酯乙酯反应，中间的双硫脲与取代的苯甲醛反应生成双芳基乙酰脲，最后由isatins和n -甲基甘氨酸原位生成1,3-偶极环加成的亚甲基酰脲。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Bis-dispiro-indolinone-pyrrolidine-imidazolones with polymethylene linkers between imidazolone fragments

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Bis-dispiro-indolinone-pyrrolidine-imidazolones with polymethylene linkers between imidazolone fragments

A method for the synthesis of bis-(dispiro-imidazolone-pyrrolidine-indolinones) in which spirocyclic fragments are linked by C4, C6 and C8 alkyl linkers between the N(3) nitrogen atoms of the imidazolone ring has been proposed. A two-step synthetic sequence was used for the synthesis, consisting of the interaction of α,ω-dialkylamines with ethyl isothiocyanatoacetate, followed by the reaction of the intermediate bis-thioureas with substituted benzaldehydes to produce bis-arylidenetiohydantoins and the final 1,3-dipolar cycloaddition of azomethine ylides generated in situ from isatins and N-methylglycine.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.