microRNA在半月板修复和再生中的治疗潜力

IF 1.6 4区医学 Q3 ORTHOPEDICS

Knee Pub Date : 2025-04-10 DOI:10.1016/j.knee.2025.03.002

George Jacob , Kazunori Shimomura , Hiroto Hanai , Taro Akimori , Tomoki Ohori , Akira Tsujii , Yu Moriguchi , Norimasa Nakamura

{"title":"microRNA在半月板修复和再生中的治疗潜力","authors":"George Jacob , Kazunori Shimomura , Hiroto Hanai , Taro Akimori , Tomoki Ohori , Akira Tsujii , Yu Moriguchi , Norimasa Nakamura","doi":"10.1016/j.knee.2025.03.002","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Managing meniscal injuries is challenging due to the complex nature of the tissue and its limited healing capacity. MicroRNAs (miRNAs) are key regulators of cellular processes, making them promising candidates for therapeutic interventions aimed at enhancing meniscal repair. This study explores the potential role of miRNAs in meniscal healing.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted in July 2024 using the PubMed (MEDLINE) and EMBASE databases, without any date restrictions. Relevant studies involving the use of miRNAs in meniscal injury or repair were identified, and a narrative review was performed.</div></div><div><h3>Results</h3><div>The search yielded three in-vitro studies and one animal study, with no clinical studies found. The identified studies suggest that miRNAs may enhance meniscal healing by promoting angiogenesis and reducing inflammation.</div></div><div><h3>Conclusions</h3><div>This review underscores the emerging potential of miRNA-based therapies for meniscal repair and regeneration. While progress has been made in understanding the mechanisms of action, several challenges remain before clinical application, including safety concerns, the need for standardized protocols, and the development of clinical-grade miRNA products.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"55 ","pages":"Pages 18-23"},"PeriodicalIF":1.6000,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Therapeutic potential of microRNA in meniscal repair and regeneration\",\"authors\":\"George Jacob , Kazunori Shimomura , Hiroto Hanai , Taro Akimori , Tomoki Ohori , Akira Tsujii , Yu Moriguchi , Norimasa Nakamura\",\"doi\":\"10.1016/j.knee.2025.03.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Managing meniscal injuries is challenging due to the complex nature of the tissue and its limited healing capacity. MicroRNAs (miRNAs) are key regulators of cellular processes, making them promising candidates for therapeutic interventions aimed at enhancing meniscal repair. This study explores the potential role of miRNAs in meniscal healing.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted in July 2024 using the PubMed (MEDLINE) and EMBASE databases, without any date restrictions. Relevant studies involving the use of miRNAs in meniscal injury or repair were identified, and a narrative review was performed.</div></div><div><h3>Results</h3><div>The search yielded three in-vitro studies and one animal study, with no clinical studies found. The identified studies suggest that miRNAs may enhance meniscal healing by promoting angiogenesis and reducing inflammation.</div></div><div><h3>Conclusions</h3><div>This review underscores the emerging potential of miRNA-based therapies for meniscal repair and regeneration. While progress has been made in understanding the mechanisms of action, several challenges remain before clinical application, including safety concerns, the need for standardized protocols, and the development of clinical-grade miRNA products.</div></div>\",\"PeriodicalId\":56110,\"journal\":{\"name\":\"Knee\",\"volume\":\"55 \",\"pages\":\"Pages 18-23\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-04-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Knee\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0968016025000626\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ORTHOPEDICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Knee","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0968016025000626","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ORTHOPEDICS","Score":null,"Total":0}

引用次数: 0

摘要

由于组织的复杂性及其有限的愈合能力，半月板损伤的治疗具有挑战性。MicroRNAs （miRNAs）是细胞过程的关键调节因子，使其成为旨在增强半月板修复的治疗干预的有希望的候选者。本研究探讨了mirna在半月板愈合中的潜在作用。方法于2024年7月使用PubMed （MEDLINE）和EMBASE数据库进行综合文献检索，无日期限制。我们确定了涉及mirna在半月板损伤或修复中的应用的相关研究，并进行了叙述性回顾。结果搜索得到3项体外研究和1项动物研究，未发现临床研究。已确定的研究表明，mirna可能通过促进血管生成和减少炎症来促进半月板愈合。结论本综述强调了基于mirna的半月板修复和再生治疗的新兴潜力。虽然在了解作用机制方面取得了进展，但在临床应用之前仍存在一些挑战，包括安全性问题、标准化方案的需求以及临床级miRNA产品的开发。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Therapeutic potential of microRNA in meniscal repair and regeneration

Background

Managing meniscal injuries is challenging due to the complex nature of the tissue and its limited healing capacity. MicroRNAs (miRNAs) are key regulators of cellular processes, making them promising candidates for therapeutic interventions aimed at enhancing meniscal repair. This study explores the potential role of miRNAs in meniscal healing.

Methods

A comprehensive literature search was conducted in July 2024 using the PubMed (MEDLINE) and EMBASE databases, without any date restrictions. Relevant studies involving the use of miRNAs in meniscal injury or repair were identified, and a narrative review was performed.

Results

The search yielded three in-vitro studies and one animal study, with no clinical studies found. The identified studies suggest that miRNAs may enhance meniscal healing by promoting angiogenesis and reducing inflammation.

Conclusions

This review underscores the emerging potential of miRNA-based therapies for meniscal repair and regeneration. While progress has been made in understanding the mechanisms of action, several challenges remain before clinical application, including safety concerns, the need for standardized protocols, and the development of clinical-grade miRNA products.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Knee 医学-外科

CiteScore

3.80

自引率

5.30%

发文量

171

审稿时长

6 months

期刊介绍： The Knee is an international journal publishing studies on the clinical treatment and fundamental biomechanical characteristics of this joint. The aim of the journal is to provide a vehicle relevant to surgeons, biomedical engineers, imaging specialists, materials scientists, rehabilitation personnel and all those with an interest in the knee. The topics covered include, but are not limited to: • Anatomy, physiology, morphology and biochemistry; • Biomechanical studies; • Advances in the development of prosthetic, orthotic and augmentation devices; • Imaging and diagnostic techniques; • Pathology; • Trauma; • Surgery; • Rehabilitation.