慢性压力通过扰乱细胞的内务管理导致抑郁

IF 48.5 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Nature Pub Date : 2025-04-09 DOI:10.1038/d41586-025-00910-w

Alberto Corona, Paul J. Kenny

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引用次数: 0

摘要

促进被称为自噬的循环过程——大脑在长期压力下受损——有可能恢复正常的神经元活动并治疗抑郁症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Chronic stress drives depression by disrupting cellular housekeeping

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Chronic stress drives depression by disrupting cellular housekeeping

Boosting the recycling process known as autophagy — impaired in the brain during prolonged stress — has the potential to restore normal neuronal activity and treat depression. Boosting the recycling process known as autophagy — impaired in the brain during prolonged stress — has the potential to restore normal neuronal activity and treat depression.

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来源期刊

Nature 综合性期刊-综合性期刊

CiteScore

90.00

自引率

1.20%

发文量

3652

审稿时长

3 months

期刊介绍： Nature is a prestigious international journal that publishes peer-reviewed research in various scientific and technological fields. The selection of articles is based on criteria such as originality, importance, interdisciplinary relevance, timeliness, accessibility, elegance, and surprising conclusions. In addition to showcasing significant scientific advances, Nature delivers rapid, authoritative, insightful news, and interpretation of current and upcoming trends impacting science, scientists, and the broader public. The journal serves a dual purpose: firstly, to promptly share noteworthy scientific advances and foster discussions among scientists, and secondly, to ensure the swift dissemination of scientific results globally, emphasizing their significance for knowledge, culture, and daily life.