光可切换的DNA g -四重体配体使转录的光学控制成为可能

IF 19.2 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nature chemistry Pub Date : 2025-04-08 DOI:10.1038/s41557-025-01796-x

引用次数: 0

摘要

一种可光切换的DNA结构特异性小分子探针，名为G4switch，已被开发用于体外和细胞内DNA g -四重复合物（G4s）的可逆靶向。这种多功能化学工具能够精确、光控地调节g4介导的基因表达和细胞增殖。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A photoswitchable DNA G-quadruplex ligand enables optical control of transcription

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A photoswitchable DNA G-quadruplex ligand enables optical control of transcription

A photoswitchable, DNA structure-specific small-molecule probe, named G4switch, has been developed for the reversible targeting of DNA G-quadruplexes (G4s) in vitro and within cells. This versatile chemical tool enables precise, light-controlled modulation of G4-mediated gene expression and cell proliferation.

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来源期刊

Nature chemistry 化学-化学综合

CiteScore

29.60

自引率

1.40%

发文量

226

审稿时长

1.7 months

期刊介绍： Nature Chemistry is a monthly journal that publishes groundbreaking and significant research in all areas of chemistry. It covers traditional subjects such as analytical, inorganic, organic, and physical chemistry, as well as a wide range of other topics including catalysis, computational and theoretical chemistry, and environmental chemistry. The journal also features interdisciplinary research at the interface of chemistry with biology, materials science, nanotechnology, and physics. Manuscripts detailing such multidisciplinary work are encouraged, as long as the central theme pertains to chemistry. Aside from primary research, Nature Chemistry publishes review articles, news and views, research highlights from other journals, commentaries, book reviews, correspondence, and analysis of the broader chemical landscape. It also addresses crucial issues related to education, funding, policy, intellectual property, and the societal impact of chemistry. Nature Chemistry is dedicated to ensuring the highest standards of original research through a fair and rigorous review process. It offers authors maximum visibility for their papers, access to a broad readership, exceptional copy editing and production standards, rapid publication, and independence from academic societies and other vested interests. Overall, Nature Chemistry aims to be the authoritative voice of the global chemical community.