Ji Qiong, Yanmei Gu, Jampa Dekyi, Dawa, Phurbu Tsring, Min Zhao, Xin Wang, Guangming Li, Haixia Liu
{"title":"西藏地区危重病人静脉血栓栓塞的风险评估和预防：一项具有历史对照的前瞻性队列研究。","authors":"Ji Qiong, Yanmei Gu, Jampa Dekyi, Dawa, Phurbu Tsring, Min Zhao, Xin Wang, Guangming Li, Haixia Liu","doi":"10.2147/RMHP.S490160","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Venous thromboembolism (VTE) is a significant concern in critically ill patients. However, the incidence and risk factors of VTE in high-altitude regions like Tibet remain unclear. This study aimed to assess the effectiveness and safety of standardized anticoagulation therapy in preventing VTE among intensive care unit (ICU) patients in Tibet.</p><p><strong>Methods: </strong>This prospective controlled study included 78 patients in the treatment group receiving low molecular weight heparin (LMWH) and 56 patients in the control group without standardized VTE prophylaxis. VTE incidence, risk factors, and safety outcomes were compared between the two groups. Patients were followed up for a minimum of one week after ICU discharge to assess VTE outcomes.</p><p><strong>Results: </strong>The incidence of VTE was significantly lower in the treatment group (35.9%) compared to the control group (42.9%, p<0.05). Risk factors for VTE included mechanical ventilation. The most common VTE type observed was deep vein thrombosis (DVT), with pulmonary embolism (PE) occurring less frequently. No significant bleeding events were observed in the treatment group.</p><p><strong>Conclusion: </strong>Standardized LMWH prophylaxis effectively reduces VTE incidence in critically ill patients in Tibet without increasing bleeding risk. Regular risk assessment and appropriate prophylaxis should be implemented in high-altitude ICU settings.</p>","PeriodicalId":56009,"journal":{"name":"Risk Management and Healthcare Policy","volume":"18 ","pages":"1171-1179"},"PeriodicalIF":2.7000,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974561/pdf/","citationCount":"0","resultStr":"{\"title\":\"Risk Assessment and Prevention of Venous Thromboembolism in Critically Ill Patients in Tibet: A Prospective Cohort Study with Historical Controls.\",\"authors\":\"Ji Qiong, Yanmei Gu, Jampa Dekyi, Dawa, Phurbu Tsring, Min Zhao, Xin Wang, Guangming Li, Haixia Liu\",\"doi\":\"10.2147/RMHP.S490160\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Venous thromboembolism (VTE) is a significant concern in critically ill patients. However, the incidence and risk factors of VTE in high-altitude regions like Tibet remain unclear. This study aimed to assess the effectiveness and safety of standardized anticoagulation therapy in preventing VTE among intensive care unit (ICU) patients in Tibet.</p><p><strong>Methods: </strong>This prospective controlled study included 78 patients in the treatment group receiving low molecular weight heparin (LMWH) and 56 patients in the control group without standardized VTE prophylaxis. VTE incidence, risk factors, and safety outcomes were compared between the two groups. Patients were followed up for a minimum of one week after ICU discharge to assess VTE outcomes.</p><p><strong>Results: </strong>The incidence of VTE was significantly lower in the treatment group (35.9%) compared to the control group (42.9%, p<0.05). Risk factors for VTE included mechanical ventilation. The most common VTE type observed was deep vein thrombosis (DVT), with pulmonary embolism (PE) occurring less frequently. No significant bleeding events were observed in the treatment group.</p><p><strong>Conclusion: </strong>Standardized LMWH prophylaxis effectively reduces VTE incidence in critically ill patients in Tibet without increasing bleeding risk. Regular risk assessment and appropriate prophylaxis should be implemented in high-altitude ICU settings.</p>\",\"PeriodicalId\":56009,\"journal\":{\"name\":\"Risk Management and Healthcare Policy\",\"volume\":\"18 \",\"pages\":\"1171-1179\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-04-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974561/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Risk Management and Healthcare Policy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/RMHP.S490160\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"HEALTH CARE SCIENCES & SERVICES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Risk Management and Healthcare Policy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/RMHP.S490160","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"HEALTH CARE SCIENCES & SERVICES","Score":null,"Total":0}
Risk Assessment and Prevention of Venous Thromboembolism in Critically Ill Patients in Tibet: A Prospective Cohort Study with Historical Controls.
Objective: Venous thromboembolism (VTE) is a significant concern in critically ill patients. However, the incidence and risk factors of VTE in high-altitude regions like Tibet remain unclear. This study aimed to assess the effectiveness and safety of standardized anticoagulation therapy in preventing VTE among intensive care unit (ICU) patients in Tibet.
Methods: This prospective controlled study included 78 patients in the treatment group receiving low molecular weight heparin (LMWH) and 56 patients in the control group without standardized VTE prophylaxis. VTE incidence, risk factors, and safety outcomes were compared between the two groups. Patients were followed up for a minimum of one week after ICU discharge to assess VTE outcomes.
Results: The incidence of VTE was significantly lower in the treatment group (35.9%) compared to the control group (42.9%, p<0.05). Risk factors for VTE included mechanical ventilation. The most common VTE type observed was deep vein thrombosis (DVT), with pulmonary embolism (PE) occurring less frequently. No significant bleeding events were observed in the treatment group.
Conclusion: Standardized LMWH prophylaxis effectively reduces VTE incidence in critically ill patients in Tibet without increasing bleeding risk. Regular risk assessment and appropriate prophylaxis should be implemented in high-altitude ICU settings.
期刊介绍：
Risk Management and Healthcare Policy is an international, peer-reviewed, open access journal focusing on all aspects of public health, policy and preventative measures to promote good health and improve morbidity and mortality in the population. Specific topics covered in the journal include:
Public and community health
Policy and law
Preventative and predictive healthcare
Risk and hazard management
Epidemiology, detection and screening
Lifestyle and diet modification
Vaccination and disease transmission/modification programs
Health and safety and occupational health
Healthcare services provision
Health literacy and education
Advertising and promotion of health issues
Health economic evaluations and resource management
Risk Management and Healthcare Policy focuses on human interventional and observational research. The journal welcomes submitted papers covering original research, clinical and epidemiological studies, reviews and evaluations, guidelines, expert opinion and commentary, and extended reports. Case reports will only be considered if they make a valuable and original contribution to the literature. The journal does not accept study protocols, animal-based or cell line-based studies.
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