Bircan Yucekaya, Seda Nur Kemer, Elif Asan, Huseyin Gerdan, Nilay Comuk Balci, Deniz Cakır, Mine Pekesen Kurtça, Murat Keskin, Murat Terzi
{"title":"本体感觉神经肌肉促进技术对多发性硬化症患者疼痛、运动功能、疲劳和健康相关生活质量的影响：一项随机、单盲研究","authors":"Bircan Yucekaya, Seda Nur Kemer, Elif Asan, Huseyin Gerdan, Nilay Comuk Balci, Deniz Cakır, Mine Pekesen Kurtça, Murat Keskin, Murat Terzi","doi":"10.1080/01616412.2025.2490086","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the effects of PNF on pain, motor function, fatigue, and quality of life in MS patients.</p><p><strong>Method: </strong>A randomized, controlled, single-blind study was conducted. Forty-four patients were randomly assigned to either the PNF Group (PNFG, <i>n</i> = 22, 16 female) or the Control Group (CG, <i>n</i> = 22, 16 female). PNFG underwent supervised combined aerobic and PNF training thrice weekly for 8 weeks, while CG followed a home exercise regimen. Various measures were employed, including the Visual Analogue Scale (VAS) for pain, Timed Up and Go (TUG) test, Functional Reach Test (FRT), Six-Minute Walk Test (6-MWT), Fatigue Severity Scale (FSS), Fatigue Impact Scale (FIS), Dexterity Questionnaire-24 (DextQ-24) and Multiple Sclerosis Quality of Life-54 (MSQoL-54).</p><p><strong>Results: </strong>PNFG exhibited significant improvements in VAS (<i>p</i> = 0.000), FRT (<i>p</i> = 0.001), TUG (<i>p</i> = 0.000), 6-MWT (<i>p</i> = 0.000), FIS (<i>p</i> = 0.007), DextQ-24 (<i>p</i> = 0.033), MSQoL-54 scores (Physical Health Composite, Mental Health Composite, <i>p</i> = 0.005, <i>p</i> = 0.002, respectively) (<i>p</i> < 0.05). CG also showed improvements in VAS (<i>p</i> = 0.018), TUG (<i>p</i> = 0.000), 6-MWT (<i>p</i> = 0.000), FSS (<i>p</i> = 0.006), psychosocial function (<i>p</i> = 0.007), MSQoL-54 (Physical Health Composite, Mental Health Composite, <i>p</i> = 0.017, <i>p</i> = 0.001, respectively), DextQ-24 ADL scores (<i>p</i> = 0.045) (<i>p</i> < 0.05). PNFG outperformed CG in DextQ-24 (Dressing, <i>p</i> = 0.038) and MSQoL-54 subscales (emotional well-being, energy, health perception, <i>p</i> = 0.007, <i>p</i> = 0.037, <i>p</i> = 0.044, respectively) (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>This is the first randomized controlled trial to show that PNF improves upper limb motor function (skill) and quality of life in MS patients. PNF and home physiotherapy effectively improved pain, motor function, fatigue and quality of life, with the PNF group achieving better outcomes. Both modalities offered accessible rehabilitation options.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.7000,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The effect of proprioceptive neuromuscular facilitation techniques on pain, motor functions, fatigue and health related quality of life in individuals with multiple sclerosis: a randomized, single-blind study.\",\"authors\":\"Bircan Yucekaya, Seda Nur Kemer, Elif Asan, Huseyin Gerdan, Nilay Comuk Balci, Deniz Cakır, Mine Pekesen Kurtça, Murat Keskin, Murat Terzi\",\"doi\":\"10.1080/01616412.2025.2490086\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>This study aimed to evaluate the effects of PNF on pain, motor function, fatigue, and quality of life in MS patients.</p><p><strong>Method: </strong>A randomized, controlled, single-blind study was conducted. Forty-four patients were randomly assigned to either the PNF Group (PNFG, <i>n</i> = 22, 16 female) or the Control Group (CG, <i>n</i> = 22, 16 female). PNFG underwent supervised combined aerobic and PNF training thrice weekly for 8 weeks, while CG followed a home exercise regimen. Various measures were employed, including the Visual Analogue Scale (VAS) for pain, Timed Up and Go (TUG) test, Functional Reach Test (FRT), Six-Minute Walk Test (6-MWT), Fatigue Severity Scale (FSS), Fatigue Impact Scale (FIS), Dexterity Questionnaire-24 (DextQ-24) and Multiple Sclerosis Quality of Life-54 (MSQoL-54).</p><p><strong>Results: </strong>PNFG exhibited significant improvements in VAS (<i>p</i> = 0.000), FRT (<i>p</i> = 0.001), TUG (<i>p</i> = 0.000), 6-MWT (<i>p</i> = 0.000), FIS (<i>p</i> = 0.007), DextQ-24 (<i>p</i> = 0.033), MSQoL-54 scores (Physical Health Composite, Mental Health Composite, <i>p</i> = 0.005, <i>p</i> = 0.002, respectively) (<i>p</i> < 0.05). CG also showed improvements in VAS (<i>p</i> = 0.018), TUG (<i>p</i> = 0.000), 6-MWT (<i>p</i> = 0.000), FSS (<i>p</i> = 0.006), psychosocial function (<i>p</i> = 0.007), MSQoL-54 (Physical Health Composite, Mental Health Composite, <i>p</i> = 0.017, <i>p</i> = 0.001, respectively), DextQ-24 ADL scores (<i>p</i> = 0.045) (<i>p</i> < 0.05). PNFG outperformed CG in DextQ-24 (Dressing, <i>p</i> = 0.038) and MSQoL-54 subscales (emotional well-being, energy, health perception, <i>p</i> = 0.007, <i>p</i> = 0.037, <i>p</i> = 0.044, respectively) (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>This is the first randomized controlled trial to show that PNF improves upper limb motor function (skill) and quality of life in MS patients. PNF and home physiotherapy effectively improved pain, motor function, fatigue and quality of life, with the PNF group achieving better outcomes. Both modalities offered accessible rehabilitation options.</p>\",\"PeriodicalId\":19131,\"journal\":{\"name\":\"Neurological Research\",\"volume\":\" \",\"pages\":\"1-13\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-04-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurological Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/01616412.2025.2490086\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurological Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/01616412.2025.2490086","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
The effect of proprioceptive neuromuscular facilitation techniques on pain, motor functions, fatigue and health related quality of life in individuals with multiple sclerosis: a randomized, single-blind study.
Purpose: This study aimed to evaluate the effects of PNF on pain, motor function, fatigue, and quality of life in MS patients.
Method: A randomized, controlled, single-blind study was conducted. Forty-four patients were randomly assigned to either the PNF Group (PNFG, n = 22, 16 female) or the Control Group (CG, n = 22, 16 female). PNFG underwent supervised combined aerobic and PNF training thrice weekly for 8 weeks, while CG followed a home exercise regimen. Various measures were employed, including the Visual Analogue Scale (VAS) for pain, Timed Up and Go (TUG) test, Functional Reach Test (FRT), Six-Minute Walk Test (6-MWT), Fatigue Severity Scale (FSS), Fatigue Impact Scale (FIS), Dexterity Questionnaire-24 (DextQ-24) and Multiple Sclerosis Quality of Life-54 (MSQoL-54).
Results: PNFG exhibited significant improvements in VAS (p = 0.000), FRT (p = 0.001), TUG (p = 0.000), 6-MWT (p = 0.000), FIS (p = 0.007), DextQ-24 (p = 0.033), MSQoL-54 scores (Physical Health Composite, Mental Health Composite, p = 0.005, p = 0.002, respectively) (p < 0.05). CG also showed improvements in VAS (p = 0.018), TUG (p = 0.000), 6-MWT (p = 0.000), FSS (p = 0.006), psychosocial function (p = 0.007), MSQoL-54 (Physical Health Composite, Mental Health Composite, p = 0.017, p = 0.001, respectively), DextQ-24 ADL scores (p = 0.045) (p < 0.05). PNFG outperformed CG in DextQ-24 (Dressing, p = 0.038) and MSQoL-54 subscales (emotional well-being, energy, health perception, p = 0.007, p = 0.037, p = 0.044, respectively) (p < 0.05).
Conclusions: This is the first randomized controlled trial to show that PNF improves upper limb motor function (skill) and quality of life in MS patients. PNF and home physiotherapy effectively improved pain, motor function, fatigue and quality of life, with the PNF group achieving better outcomes. Both modalities offered accessible rehabilitation options.
期刊介绍：
Neurological Research is an international, peer-reviewed journal for reporting both basic and clinical research in the fields of neurosurgery, neurology, neuroengineering and neurosciences. It provides a medium for those who recognize the wider implications of their work and who wish to be informed of the relevant experience of others in related and more distant fields.
The scope of the journal includes:
•Stem cell applications
•Molecular neuroscience
•Neuropharmacology
•Neuroradiology
•Neurochemistry
•Biomathematical models
•Endovascular neurosurgery
•Innovation in neurosurgery.
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