内部工作:细胞内C3的作用。

IF 11.4 1区 医学 Q1 ALLERGY
Behdad Afzali, Parul Singh, Md Tajmul, Claudia Kemper
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引用次数: 0

摘要

我们对补体系统的认识在不断加深,它已不仅仅是源自肝脏的系统性病原体清除机制,而是单细胞行为和组织生物学的核心协调者。这些扩展的活动反映了许多细胞(如果不是大多数细胞的话)在肝外和局部产生补体,以及最近意外发现补体也在细胞内发挥重要的生理作用。补体核心成分 C3 在细胞基本功能中扮演着尤为关键的角色。在这里,我们将概述目前已知的细胞内 C3 的形式和功能以及控制它的机制。我们还讨论了作为未来潜在关键探索领域的两个新兴概念:细胞内 C3 作为宿主-环境界面上病原体防御的第二层以及 "C3 许可"。最后,我们建议应更好地探讨细胞内 C3 活性扰动的潜在临床影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Inside Job: Roles of Intracellular C3.

Our understanding of the complement system continues to grow beyond that of a liver-derived systemically operative mechanism of pathogen clearance to a central orchestrator of single cell behavior and tissue biology. These expanded activities reflect the extra-hepatic and local production of complement by many, if not most, cells, and the unexpected recent finding that complement also serves important physiological intracellular roles. The complement core component C3 has emerged as a particularly critical player in basic cell functions. Here, we provide an overview of the currently known forms and functions of intracellular C3 and the mechanisms that control it. We also discuss two emerging concepts as potential key areas for future exploration: intracellular C3 as second layer of pathogen defence at host-environmental interfaces and "C3 licensing". We conclude by suggesting that the potential clinical implications surrounding perturbations in intracellular C3 activities should be explored better.

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来源期刊
CiteScore
25.90
自引率
7.70%
发文量
1302
审稿时长
38 days
期刊介绍: The Journal of Allergy and Clinical Immunology is a prestigious publication that features groundbreaking research in the fields of Allergy, Asthma, and Immunology. This influential journal publishes high-impact research papers that explore various topics, including asthma, food allergy, allergic rhinitis, atopic dermatitis, primary immune deficiencies, occupational and environmental allergy, and other allergic and immunologic diseases. The articles not only report on clinical trials and mechanistic studies but also provide insights into novel therapies, underlying mechanisms, and important discoveries that contribute to our understanding of these diseases. By sharing this valuable information, the journal aims to enhance the diagnosis and management of patients in the future.
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