抗艾滋病毒mRNA疫苗:希望与挑战。

IF 2.8 3区 医学 Q2 INFECTIOUS DISEASES
HIV Medicine Pub Date : 2025-04-07 DOI:10.1111/hiv.70024
Akmal Zubair, Hanbal Ahmad, Muhammad Muaz Arif, Muhammad Ali
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引用次数: 0

摘要

背景:自首个获得许可的基于mrna的COVID-19疫苗问世以来,人们对利用这一技术生产其他疫苗非常感兴趣。自2020年以来,mRNA疫苗在临床前、临床和各个研究阶段出现了前所未有的激增。mRNA配方、递送方法和制造工艺的快速发展使得这一趋势可以预见。在病毒流行的地区,迫切需要有效和易于运输的疫苗,mRNA技术有望满足这一需求。方法:数据从各种数据库检索,包括谷歌Scholar、PubMed、Science Direct、ClinicalTrials.gov和政府网站。搜索策略中使用了以下术语:HIV、疫苗、mRNA疫苗、临床试验和临床前试验。总共鉴定了35篇文章,并随后筛选了有关艾滋病毒mRNA疫苗的数据。结果:mRNA疫苗是一种有效的艾滋病毒治疗方案,正如文章中引用的各种研究所证明的那样。结论:本综述评估了HIV-1 mRNA疫苗开发的现状,阐明了各种靶向策略,突出了最近的研究成果,并提供了与这些问题相关的挑战和潜在解决方案的见解。在这篇综述中,我们探讨了mRNA疫苗,重点是它们的功能结构、设计、制造和分布方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
mRNA vaccines against HIV: Hopes and challenges.

Background: Since the introduction of the first licensed mRNA-based vaccines against COVID-19, there has been significant interest in leveraging this technology for other vaccines. An unprecedented surge of mRNA vaccines has emerged in preclinical, clinical, and various research phases since 2020. The rapid development of mRNA formulations, delivery methods, and manufacturing processes has made this trend foreseeable. There is an urgent demand for effective and easily transportable vaccines in regions where the virus is prevalent, and mRNA technology shows promise in addressing this need.

Methodology: The data was retrieved from various databases, including Google Scholar, PubMed, Science Direct, ClinicalTrials.gov, and government websites. The following terms were used in the search strategies: HIV, vaccines, mRNA vaccines, clinical trials, and preclinical trials. A total of 35 articles were identified and subsequently screened for data regarding mRNA vaccines for HIV.

Results: mRNA vaccines are an effective solution for HIV treatment, as demonstrated by various research studies referenced in the article.

Conclusion: This review evaluates the current state of HIV-1 mRNA vaccine development, clarifies various targeting strategies, highlights recent research findings, and provides insights into the challenges and potential solutions associated with these issues. In this review, we have explored mRNA vaccines, focusing on their functional structure, design, manufacturing, and distribution methodologies.

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来源期刊
HIV Medicine
HIV Medicine 医学-传染病学
CiteScore
5.10
自引率
10.00%
发文量
167
审稿时长
6-12 weeks
期刊介绍: HIV Medicine aims to provide an alternative outlet for publication of international research papers in the field of HIV Medicine, embracing clinical, pharmocological, epidemiological, ethical, preclinical and in vitro studies. In addition, the journal will commission reviews and other feature articles. It will focus on evidence-based medicine as the mainstay of successful management of HIV and AIDS. The journal is specifically aimed at researchers and clinicians with responsibility for treating HIV seropositive patients.
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