{"title":"嗜酸乳杆菌对肉鸡生产性能和免疫的影响及其机制","authors":"Jinmei Liu, Hongxia Gu, Rui Jia, Shuzhen Li, Zhimin Chen, Aijuan Zheng, Wenhuan Chang, Guohua Liu","doi":"10.3389/fvets.2025.1554502","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong><i>Lactobacillus</i> species have attracted more and more attention as a potential antibiotic substitute for human health and animal production due to their remarkable antibacterial effects. However, the underlying mechanism is unclear. This experiment's goal was to investigate the impacts of lactic acid bacteria (LAB) on the growth performance, carcass characteristics, immune function of broiler chickens and their mechanism.</p><p><strong>Methods: </strong>One hundred and eighty 1-day-old AA broilers were used and randomly allocated into 3 treatment groups with 6 replicates of 10 chickens per replicate. The 3 treatment groups were control group (CK), <i>L. acidophilus</i> added group (LAB-E, 1.0 × 108 CFU/kg) for the first 7 days; <i>L. acidophilus</i> added group (LAB-A, 1.0 × 108 CFU/kg) for the whole experimental period. Broilers had free access to water and feed.</p><p><strong>Results: </strong>The results showed that addition of L. acidophilus for the whole experimental period significantly decreased ADFI, FCR and the abdominal fat percentage of broilers (<i>p</i> < 0.05), tended to increase the levels of IgG in broiler serum (<i>p</i> = 0.093). The LAB-A group had higher HDL-C content and IL-2, IL-4 content, and lower level of LPS in broiler serum compared to the controls (<i>p</i> < 0.05).</p><p><strong>Discussion: </strong>In conclusion, <i>L. acidophilus</i> improved feed efficiency and immune function of broilers by controlling nutrient metabolism and inflammation responses of broilers. <i>L. acidophilus</i> can be used as a potential substitute for antibiotics in broiler production.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1554502"},"PeriodicalIF":2.6000,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974341/pdf/","citationCount":"0","resultStr":"{\"title\":\"Effects of <i>Lactobacillus acidophilus</i> on production performance and immunity of broiler chickens and their mechanism.\",\"authors\":\"Jinmei Liu, Hongxia Gu, Rui Jia, Shuzhen Li, Zhimin Chen, Aijuan Zheng, Wenhuan Chang, Guohua Liu\",\"doi\":\"10.3389/fvets.2025.1554502\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong><i>Lactobacillus</i> species have attracted more and more attention as a potential antibiotic substitute for human health and animal production due to their remarkable antibacterial effects. However, the underlying mechanism is unclear. This experiment's goal was to investigate the impacts of lactic acid bacteria (LAB) on the growth performance, carcass characteristics, immune function of broiler chickens and their mechanism.</p><p><strong>Methods: </strong>One hundred and eighty 1-day-old AA broilers were used and randomly allocated into 3 treatment groups with 6 replicates of 10 chickens per replicate. The 3 treatment groups were control group (CK), <i>L. acidophilus</i> added group (LAB-E, 1.0 × 108 CFU/kg) for the first 7 days; <i>L. acidophilus</i> added group (LAB-A, 1.0 × 108 CFU/kg) for the whole experimental period. Broilers had free access to water and feed.</p><p><strong>Results: </strong>The results showed that addition of L. acidophilus for the whole experimental period significantly decreased ADFI, FCR and the abdominal fat percentage of broilers (<i>p</i> < 0.05), tended to increase the levels of IgG in broiler serum (<i>p</i> = 0.093). The LAB-A group had higher HDL-C content and IL-2, IL-4 content, and lower level of LPS in broiler serum compared to the controls (<i>p</i> < 0.05).</p><p><strong>Discussion: </strong>In conclusion, <i>L. acidophilus</i> improved feed efficiency and immune function of broilers by controlling nutrient metabolism and inflammation responses of broilers. <i>L. acidophilus</i> can be used as a potential substitute for antibiotics in broiler production.</p>\",\"PeriodicalId\":12772,\"journal\":{\"name\":\"Frontiers in Veterinary Science\",\"volume\":\"12 \",\"pages\":\"1554502\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-03-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974341/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Veterinary Science\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.3389/fvets.2025.1554502\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Veterinary Science","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.3389/fvets.2025.1554502","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
Effects of Lactobacillus acidophilus on production performance and immunity of broiler chickens and their mechanism.
Introduction: Lactobacillus species have attracted more and more attention as a potential antibiotic substitute for human health and animal production due to their remarkable antibacterial effects. However, the underlying mechanism is unclear. This experiment's goal was to investigate the impacts of lactic acid bacteria (LAB) on the growth performance, carcass characteristics, immune function of broiler chickens and their mechanism.
Methods: One hundred and eighty 1-day-old AA broilers were used and randomly allocated into 3 treatment groups with 6 replicates of 10 chickens per replicate. The 3 treatment groups were control group (CK), L. acidophilus added group (LAB-E, 1.0 × 108 CFU/kg) for the first 7 days; L. acidophilus added group (LAB-A, 1.0 × 108 CFU/kg) for the whole experimental period. Broilers had free access to water and feed.
Results: The results showed that addition of L. acidophilus for the whole experimental period significantly decreased ADFI, FCR and the abdominal fat percentage of broilers (p < 0.05), tended to increase the levels of IgG in broiler serum (p = 0.093). The LAB-A group had higher HDL-C content and IL-2, IL-4 content, and lower level of LPS in broiler serum compared to the controls (p < 0.05).
Discussion: In conclusion, L. acidophilus improved feed efficiency and immune function of broilers by controlling nutrient metabolism and inflammation responses of broilers. L. acidophilus can be used as a potential substitute for antibiotics in broiler production.
期刊介绍：
Frontiers in Veterinary Science is a global, peer-reviewed, Open Access journal that bridges animal and human health, brings a comparative approach to medical and surgical challenges, and advances innovative biotechnology and therapy.
Veterinary research today is interdisciplinary, collaborative, and socially relevant, transforming how we understand and investigate animal health and disease. Fundamental research in emerging infectious diseases, predictive genomics, stem cell therapy, and translational modelling is grounded within the integrative social context of public and environmental health, wildlife conservation, novel biomarkers, societal well-being, and cutting-edge clinical practice and specialization. Frontiers in Veterinary Science brings a 21st-century approach—networked, collaborative, and Open Access—to communicate this progress and innovation to both the specialist and to the wider audience of readers in the field.
Frontiers in Veterinary Science publishes articles on outstanding discoveries across a wide spectrum of translational, foundational, and clinical research. The journal''s mission is to bring all relevant veterinary sciences together on a single platform with the goal of improving animal and human health.
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