Brønsted酸催化一步高效合成高产选择性丙交酯。

IF 7.5 2区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

ChemSusChem Pub Date : 2025-04-08 DOI:10.1002/cssc.202500100

Yingjie Zhao, Wenqi Qiu, Yukang Liu, Yufei Zhang, Xiaotao Wang, Yuman Guo, Hui Liu, Canbin Ouyang, Zongxia Guo

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引用次数: 0

摘要

本文报道了一步法合成丙交酯的方法，取代了传统的两步法。选择合适的酸性催化剂聚磷酸（PPA），优化反应条件，收率达97%。此外，这种新的一步策略消除了对金属催化剂的需求，不需要高温条件，从而避免了外消旋化的问题。简单的一步策略提供了效率，可持续性和产品质量改进的组合，使其成为丙交酯合成的现代实用方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Efficient One-Step Synthesis of Lactide with High Yield and Selectivity Using Brønsted Acid Catalysis.

In this work, a one-step method synthesis of lactide was reported instead of the traditional two-step method. The selection of a suitable acid catalyst polyphosphoric acid (PPA) and optimization of reaction conditions resulted in a yield of 97%. Moreover, this new one-step strategy eliminates the need for metal catalysts and does not require high-temperature conditions, thereby avoiding the issue of racemization. The simple one-step strategy offers a combination of efficiency, sustainability, and product quality improvements, making it a modern, practical approach to lactide synthesis.

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来源期刊

ChemSusChem 化学-化学综合

CiteScore

15.80

自引率

4.80%

发文量

555

审稿时长

1.8 months

期刊介绍： ChemSusChem Impact Factor (2016): 7.226 Scope: Interdisciplinary journal Focuses on research at the interface of chemistry and sustainability Features the best research on sustainability and energy Areas Covered: Chemistry Materials Science Chemical Engineering Biotechnology