杏仁核神经变性可区分脑先性和体先性帕金森病：核磁共振成像研究

IF 3.1 3区医学 Q2 CLINICAL NEUROLOGY

Parkinsonism & related disorders Pub Date : 2025-04-09 DOI:10.1016/j.parkreldis.2025.107827

Nils Schröter , Laura Matinpalo , Jonas A. Hosp , Marco Reisert , Lea Philpsen , Wolfgang H. Jost , Heinz Wiendl , Horst Urbach , Michel Rijntjes , Alexander Rau

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Amygdala neurodegeneration differentiates brain-first and body-first Parkinson's disease: An MRI study

Background

Two distinct patterns of alpha-synuclein spread in Parkinson's disease were proposed with a body-first and a brain-first subtype. The body-first subtype originates in the periphery, while the brain-first subtype initiates in the central nervous system, notably affecting the amygdala.

Objectives

This retrospective cross-sectional study compared the integrity of the substantia nigra and amygdala between body-first and brain-first Parkinson's disease subtypes.

Methods

We analyzed data from 30 Parkinson's disease patients, classified into body-first (n = 21) and brain-first (n = 9) subtypes based on REM sleep behavior disorder history. Microstructural integrity was assessed using diffusion microstructure MRI.

Results

No significant differences were found in the substantia nigra between subtypes. However, amygdala degeneration was significantly pronounced in the “brain-first” compared to the “body-first” group reflected by increased free interstitial fluid (p = 0.02, Cohen's d = −1.22).

Conclusions

The degeneration of amygdala is distinctively pronounced in “brain-first” Parkinson's disease, supporting differential disease progression patterns between subtypes.

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来源期刊

Parkinsonism & related disorders 医学-临床神经学

CiteScore

6.20

自引率

4.90%

发文量

292

审稿时长

39 days

期刊介绍： Parkinsonism & Related Disorders publishes the results of basic and clinical research contributing to the understanding, diagnosis and treatment of all neurodegenerative syndromes in which Parkinsonism, Essential Tremor or related movement disorders may be a feature. Regular features will include: Review Articles, Point of View articles, Full-length Articles, Short Communications, Case Reports and Letter to the Editor.